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超氧化物与其他还原剂在生物产生羟基自由基过程中的比较。

Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals.

作者信息

Winterbourn C C

出版信息

Biochem J. 1979 Aug 15;182(2):625-8. doi: 10.1042/bj1820625.

DOI:10.1042/bj1820625
PMID:41521
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161347/
Abstract

Iron--EDTA was shown to catalyse OH. production from H2O2 and ascorbate by a mechanism largely independent of superoxide. When ascorbate and superoxide were both present, the ascorbate mechanism was more important than superoxide as a source of OH., and would appear to be more significantly biologically.

摘要

铁-乙二胺四乙酸（Iron--EDTA）被证明可通过一种很大程度上独立于超氧化物的机制催化过氧化氢（H2O2）和抗坏血酸盐产生羟基自由基（OH.）。当抗坏血酸盐和超氧化物同时存在时，作为羟基自由基来源，抗坏血酸盐机制比超氧化物机制更重要，而且在生物学上似乎更显著。

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本文引用的文献

1
A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase.一种由甲硫醛生成乙烯的机制。黄嘌呤氧化酶产生羟基自由基。
J Biol Chem. 1970 Sep 25;245(18):4641-6.
2
An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase.基于酶的专性厌氧菌理论：超氧化物歧化酶的生理功能。
Proc Natl Acad Sci U S A. 1971 May;68(5):1024-7. doi: 10.1073/pnas.68.5.1024.
3
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.生物防御机制。白细胞产生超氧化物，一种潜在的杀菌剂。
J Clin Invest. 1973 Mar;52(3):741-4. doi: 10.1172/JCI107236.
4
Superoxide dismutases.超氧化物歧化酶
Annu Rev Biochem. 1975;44:147-59. doi: 10.1146/annurev.bi.44.070175.001051.
5
The mechanism of oxidative hemolysis produced by phenylhydrazine.
Mol Pharmacol. 1977 Sep;13(5):832-9.
6
Ethylene formation from methional.由甲硫醛生成乙烯。
Biochem Biophys Res Commun. 1978 Mar 30;81(2):498-503. doi: 10.1016/0006-291x(78)91562-0.
7
Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex.铁-乙二胺四乙酸络合物催化的超氧化物依赖性羟基自由基生成。
FEBS Lett. 1978 Feb 1;86(1):139-42. doi: 10.1016/0014-5793(78)80116-1.
8
Hemolysis of human erythrocytes by activated oxygen species.活性氧对人红细胞的溶血作用。
Photochem Photobiol. 1977 Jan;25(1):55-63. doi: 10.1111/j.1751-1097.1977.tb07424.x.
9
Stopped flow spectrophotometric observation of superoxide dismutation in aqueous solution.水溶液中超氧化物歧化反应的停流分光光度观察
FEBS Lett. 1976 Sep 1;67(3):294-8. doi: 10.1016/0014-5793(76)80550-9.
10
Ascorbic acid, metal ions and the superoxide radical.抗坏血酸、金属离子与超氧自由基。
Biochem J. 1976 Jun 1;155(3):697-700. doi: 10.1042/bj1550697.