人肺泡巨噬细胞产生羟基自由基。
Production of hydroxyl radical by human alveolar macrophages.
作者信息
Hoidal J R, Beall G D, Repine J E
出版信息
Infect Immun. 1979 Dec;26(3):1088-92. doi: 10.1128/iai.26.3.1088-1092.1979.
Abstract
Stimulated human alveolar macrophages were demonstrated to oxidize B-methyl proprionaldehyde (methional) or 2-keto-4-thiomethylbutyric acid to ethylene (C2H4). Agents which are believed to scavenge the hydroxyl radical (.OH), sodium benzoate, and mannitol, as well as scavengers of superoxide anion (O2-) or hydrogen peroxide, decreased C2H4 production, implicaing .OH as the oxidizing radical. Differences in C2H4 rpoduction, as well as oxygen uptake and O2- release between human alveolar macrophages and polymorphonuclear leukocytes, were also documented.
摘要
已证实，受刺激的人肺泡巨噬细胞可将β-甲基丙醛（甲硫醛）或2-酮-4-硫代甲基丁酸氧化为乙烯（C2H4）。据信可清除羟自由基（·OH）的试剂、苯甲酸钠和甘露醇，以及超氧阴离子（O2-）或过氧化氢的清除剂，均可降低C2H4的生成，这表明·OH是氧化自由基。还记录了人肺泡巨噬细胞与多形核白细胞在C2H4生成、氧摄取和O2-释放方面的差异。
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