Binz H, Lindenmann J, Wigzell H
J Exp Med. 1974 Sep 1;140(3):731-41. doi: 10.1084/jem.140.3.731.
The rat popliteal node graft-vs.-host assay was shown to depend on the presence of parental T cells in the inoculum. Antialloantisera raised in F(1) hybrid rats against alloantibodies of one parent directed at transplantation antigens of the other parent displayed some or all of the following specific effects on parental T cells: They inhibited local GvH by purified T-cell suspensions; they blocked the capacity of GvH-reactive cells to adsorb onto fibroblast monolayers of the relevant genotype; together with complement, they killed GvH-reactive cells.
大鼠腘淋巴结移植物抗宿主试验表明,其依赖于接种物中亲代T细胞的存在。在F(1)杂种大鼠中产生的针对一方亲代针对另一方亲代移植抗原的同种抗体的抗同种抗血清,对亲代T细胞表现出以下部分或全部特异性作用:它们抑制纯化的T细胞悬液的局部移植物抗宿主反应;它们阻断移植物抗宿主反应性细胞吸附到相关基因型成纤维细胞单层上的能力;与补体一起,它们杀死移植物抗宿主反应性细胞。