McKearn T J
Science. 1974 Jan 11;183(4120):94-6. doi: 10.1126/science.183.4120.94.
The antigen receptor of lymphocytes destined to form antibody appears to have the characteristics of the immunoglobulin produced. Antibody directed against the combining region of this immunoglobulin should interact with the combining region of the cell receptor for the antigen. Purified Lewis rat alloantibody prepared against Brown Norway (BN) rat histocompatibility antigens was used to immunize L x BN F(1) hybrids. The resultant antiserum has anti-receptor activity because (i) it yields precipitin lines in gel diffusion when reacted against the immunizing alloantibody; (ii) it inhibits the hemagglutinin antibody response of Lewis rats to BN histocompatibility antigens; and (iii) it inhibits the local graft-versus-host response of Lewis lymphoid cells against BN antigens. This suggests that antireceptor antibody may inhibit cell-mediated responses as well as antibody responses to histocompatibility antigens and may play a role in the regulation of immune responses to such antigens.
注定要形成抗体的淋巴细胞的抗原受体似乎具有所产生的免疫球蛋白的特性。针对这种免疫球蛋白结合区域的抗体应与细胞对抗原的受体结合区域相互作用。用针对棕色挪威（BN）大鼠组织相容性抗原制备的纯化Lewis大鼠同种抗体免疫L×BN F(1)杂种。所得抗血清具有抗受体活性，因为：（i）它与免疫同种抗体反应时在凝胶扩散中产生沉淀线；（ii）它抑制Lewis大鼠对BN组织相容性抗原的血凝素抗体反应；（iii）它抑制Lewis淋巴细胞对BN抗原的局部移植物抗宿主反应。这表明抗受体抗体可能抑制细胞介导的反应以及对组织相容性抗原的抗体反应，并可能在对此类抗原的免疫反应调节中发挥作用。
