细胞受体。抗同种异体抗血清对移植抗原识别的影响。
Cellular receptors. effect of anti-alloantiserum on the recognition of transplantation antigens.
作者信息
Ramseier H, Lindenmann J
出版信息
J Exp Med. 1971 Nov 1;134(5):1083-94. doi: 10.1084/jem.134.5.1083.
Abstract
The possibility that a rat alloantiserum DA anti-Lewis possesses similar recognition structures for Lewis transplantation antigens, as do DA immunocompetent cells, was investigated by raising an antiserum against this alloantiserum in (Lewis x DA)F(1) hosts. This antiserum, as well as one provoked by injecting DA lymphoid cells, was active against recognition structures for Lewis antigens of DA immunocompetent cells. The anti-(DA anti-Lewis) antiserum displayed the same degree of specificity as was found previously for anti-recognition structure sera prepared by injecting parental strain lymphoid cells into F(1) hosts. Since the activities of antisera raised against cell-bound receptors or against the antigen-binding region of an immunoglobulin were indistinguishable, it was concluded that the functional part of cell-associated receptors might be structurally similar to the variable portion of an immunoglobulin.
摘要
通过在（Lewis×DA）F1宿主中制备针对这种同种异体抗血清的抗血清，研究了大鼠同种异体抗血清DA抗Lewis是否具有与DA免疫活性细胞相同的Lewis移植抗原识别结构。这种抗血清以及注射DA淋巴细胞激发产生的抗血清，对DA免疫活性细胞的Lewis抗原识别结构具有活性。抗（DA抗Lewis）抗血清表现出与先前通过将亲代菌株淋巴细胞注入F1宿主制备的抗识别结构血清相同程度的特异性。由于针对细胞结合受体或免疫球蛋白抗原结合区域产生的抗血清活性无法区分，因此得出结论，细胞相关受体的功能部分在结构上可能与免疫球蛋白的可变部分相似。
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J Exp Med. 1971 Nov 1;134(5):1083-94. doi: 10.1084/jem.134.5.1083.
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引用本文的文献
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2
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本文引用的文献
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Individual Antigenic Specificity of Isolated Antibodies.分离抗体的个体抗原特异性
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STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM.家兔淋巴细胞的体外研究。I. 用抗独特型血清刺激母细胞转化
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INVASION AND DESTRUCTION OF HOMOLOGOUS KIDNEY BY LOCALLY INOCULATED LYMPHOID CELLS.局部接种的淋巴细胞对同种肾的侵袭与破坏
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DISTRIBUTION OF PROLIFERATING DONOR CELLS IN RUNT DISEASE IN RATS.大鼠 runt 病中增殖供体细胞的分布
Transplantation. 1964 May;2:375-82. doi: 10.1097/00007890-196405000-00006.
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Donor and host contribution to splenomegaly in homologous mouse chimaeras.供体和宿主对同源小鼠嵌合体脾肿大的影响。
Nature. 1963 Feb 16;197:673-5. doi: 10.1038/197673a0.
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An antibody response to skin homografts in mice.小鼠对皮肤同种异体移植的抗体反应。
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Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells.抗原包被柱上的细胞分离。去除高速率抗体形成细胞和免疫记忆细胞。
J Exp Med. 1969 Jan 1;129(1):23-36. doi: 10.1084/jem.129.1.23.
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J Exp Med. 1970 Jul 1;132(1):110-26. doi: 10.1084/jem.132.1.110.
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