亚急性硬化性全脑炎患者血清和脑脊液中麻疹病毒核衣壳特异性IgGκ抗体的独特型
Idiotypy of measles virus nucleocapsid-specific IgGkappa antibody in serum and cerebrospinal fluid in subacute sclerosing panencephalitis.
作者信息
Nodal H J, Vandvik B, Natvig J B
出版信息
Scand J Immunol. 1977;6(12):1351-6. doi: 10.1111/j.1365-3083.1977.tb00377.x.
A gel-precipitating anti-idiotypic antiserum was prepared in a rabbit by immunization with measles virus-specific IgG isolated from the serum of a patient with subacute sclerosing pancencephalitis (SSPE). The idiotypic determinant was associated with an electrophoretically restricted and cathodally migrating IgGkappa protein in serum and cerebrospinal fluid (CSF) with antibody activity to measles nucleocapsids. The anti-idiotypic antiserum did not precipitate with other oligoclonal populations of measles-specific IgG in the patients serum or CSF, nor with serum or CSF from 4 other patients with SSPE and 10 patients with multiple sclerosis.
通过用从亚急性硬化性全脑炎（SSPE）患者血清中分离出的麻疹病毒特异性IgG免疫兔子，制备了一种凝胶沉淀抗独特型抗血清。独特型决定簇与血清和脑脊液（CSF）中一种电泳受限且向阴极迁移的IgGκ蛋白相关，该蛋白对麻疹核衣壳具有抗体活性。该抗独特型抗血清不会与患者血清或CSF中其他麻疹特异性IgG的寡克隆群体沉淀，也不会与另外4名SSPE患者和10名多发性硬化症患者的血清或CSF沉淀。
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