Kasturi J, Saraya A K
Acta Haematol. 1978;59(2):104-13. doi: 10.1159/000207751.
Platelet functions were studied in 16 patients with multiple myeloma (MM) and 4 with primary macroglobulinemia (PM). The fall in immunoglobulins on therapy was correlated with the status of platelet function. Effect of incubation of normal platelets with immunoglobulins derived from these patients on kaolin-induced platelet factor 3 (PF3) release was studied to elucidate the mechanism of platelet function defect. Results show increased bleeding time, absence or poor platelet adhesion and aggregation, poor PF3 availability and reduced total PF3 in platelets more consistently in PM but to a lesser extent in MM. Normalisation or partial reduction in globulins on therapy was associated with improvement in platelet functions. Incubation of normal platelets with immunoglobulins enhanced the kaolin-induced PF3 availability. It is suggested that in vivo platelet activation may bring about the PF3 release which subsequently manifests as poor PF3 availability and reduction in its total contents.
对16例多发性骨髓瘤（MM）患者和4例原发性巨球蛋白血症（PM）患者的血小板功能进行了研究。治疗过程中免疫球蛋白的下降与血小板功能状态相关。研究了用这些患者来源的免疫球蛋白孵育正常血小板对高岭土诱导的血小板因子3（PF3）释放的影响，以阐明血小板功能缺陷的机制。结果显示，出血时间延长，血小板黏附与聚集缺乏或不良，PF3活性降低，血小板中总PF3含量减少，PM患者表现更为一致，但MM患者程度较轻。治疗后球蛋白正常化或部分降低与血小板功能改善相关。用免疫球蛋白孵育正常血小板可增强高岭土诱导的PF3活性。提示体内血小板激活可能导致PF3释放，随后表现为PF3活性降低及其总含量减少。
