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进行性风疹病毒全脑炎：中枢神经系统中寡克隆病毒特异性IgG抗体和均一游离轻链的合成。

Progressive rubella virus panencephalitis: synthesis of oligoclonal virus-specific IgG antibodies and homogeneous free light chains in the central nervous system.

作者信息

Vandvik B, Weil M L, Grandien M, Norrby E

出版信息

Acta Neurol Scand. 1978 Jan;57(1):53-64. doi: 10.1111/j.1600-0404.1978.tb04497.x.

DOI:10.1111/j.1600-0404.1978.tb04497.x
PMID:415504
Abstract

The occurrence of oligoclonal IgG and homogeneous free lambda light chains in the cerebrospinal fluid (CSF) of a patient with progressive rubella virus panencephalitis is reported. Fractions of oligoclonal IgG corresponding to those of the CSF occurred also in the serum. Evidence is presented that the oligoclonal IgG of serum and CSF represent rubella virus-specific antibodies. Different populations of oligoclonal IgG appear to be associated with antibody specificities to different antigenic components of the virus.

摘要

本文报道了一名进行性风疹病毒全脑炎患者脑脊液（CSF）中寡克隆IgG和均一性游离λ轻链的出现情况。血清中也出现了与脑脊液中相对应的寡克隆IgG组分。有证据表明，血清和脑脊液中的寡克隆IgG代表风疹病毒特异性抗体。不同群体的寡克隆IgG似乎与针对病毒不同抗原成分的抗体特异性相关。

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Progressive rubella virus panencephalitis: synthesis of oligoclonal virus-specific IgG antibodies and homogeneous free light chains in the central nervous system.进行性风疹病毒全脑炎：中枢神经系统中寡克隆病毒特异性IgG抗体和均一游离轻链的合成。
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引用本文的文献

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J Virol. 2017 Nov 14;91(23). doi: 10.1128/JVI.01352-17. Print 2017 Dec 1.
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Intrathecal humoral immunity to encephalitic RNA viruses.鞘内体液免疫反应对脑炎 RNA 病毒的影响
Viruses. 2013 Feb 15;5(2):732-52. doi: 10.3390/v5020732.
3
Persistent rubella-specific IgM-antibody in the cerebrospinal fluid of a child with congenital rubella.
先天性风疹患儿脑脊液中持续存在风疹特异性IgM抗体。
Arch Dis Child. 1980 Jan;55(1):46-8. doi: 10.1136/adc.55.1.46.
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Immunochemical features of a case of progressive rubella panencephalitis.一例进行性风疹全脑炎的免疫化学特征
Clin Exp Immunol. 1982 May;48(2):359-66.
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Yale J Biol Med. 1980 Jan-Feb;53(1):101-7.
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