大鼠感染鼠冠状病毒所致脑脊髓炎：血清和脑脊液中免疫球蛋白及病毒特异性抗体分析
Murine coronavirus-induced encephalomyelitis in rats: analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid.
作者信息
Dörries R, Watanabe R, Wege H, ter Meulen V
出版信息
J Neuroimmunol. 1986 Aug;12(2):131-42. doi: 10.1016/0165-5728(86)90026-3.
Abstract
The humoral intrathecal immune response in coronavirus-induced demyelinating encephalomyelitis in rats associated with an autoimmune reaction to brain antigen, was analysed. The CSF of these animals revealed immune reactions which were directed against coronavirus and other, unknown, antigens. In general, no direct correlation between the disease, the state of the blood-brain barrier (BBB), intrathecal synthesis of Ig and the presence of virus-specific antibodies was detectable, suggesting that the humoral, in contrast to the cellular, immune response does not play a significant pathogenetic role in this CNS disease.
摘要
对大鼠冠状病毒诱导的脱髓鞘性脑脊髓炎中与脑抗原自身免疫反应相关的体液鞘内免疫反应进行了分析。这些动物的脑脊液显示出针对冠状病毒和其他未知抗原的免疫反应。总体而言，未检测到疾病、血脑屏障（BBB）状态、鞘内Ig合成与病毒特异性抗体存在之间的直接相关性，这表明与细胞免疫反应相比，体液免疫反应在这种中枢神经系统疾病中不发挥重要的致病作用。
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