柳氮磺胺吡啶（水杨酸偶氮磺胺吡啶）对炎症性肠病患者粪便菌群的影响。
Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease.
作者信息
West B, Lendrum R, Hill M J, Walker G
出版信息
Gut. 1974 Dec;15(12):960-5. doi: 10.1136/gut.15.12.960.
Abstract
The faecal flora of 21 patients with proctocolitis and five patients with Crohn's disease of the large bowel was examined both while sulphasalazine was being administered and during control periods. Patients with proctocolitis and Crohn's disease who were not receiving sulphasalazine had a similar flora which did not differ in any way from the normal. The effect of sulphasalazine was to decrease the numbers of opalescent-negative clostridia, enterobacteria, and total non-sporing anaerobes. It is suggested that this antibacterial effect of sulphasalazine, which has not been previously demonstrated, may be related to the beneficial effects of this drug in proctocolitis and should be investigated further.
摘要
对21例直肠结肠炎患者和5例大肠克罗恩病患者的粪便菌群在服用柳氮磺胺吡啶期间及对照期进行了检查。未服用柳氮磺胺吡啶的直肠结肠炎和克罗恩病患者的菌群相似，与正常菌群无任何差异。柳氮磺胺吡啶的作用是减少乳白色阴性梭菌、肠杆菌和总的无芽孢厌氧菌的数量。有人提出，柳氮磺胺吡啶的这种抗菌作用此前未得到证实，可能与该药对直肠结肠炎的有益作用有关，应进一步研究。
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