Ingenbleek Y, Beckers C
Am J Clin Nutr. 1978 Mar;31(3):408-15. doi: 10.1093/ajcn/31.3.408.
The thyroid function was evaluated in two comparable groups of 12 protein-calorie malnourished children respectively by oral and intravenous test using radioiodine 131I. Maximal radioiodide uptake (RAIUmax) peaked within 24 hr in the intravenously investigated children, but only after 48 hr in the orally investigated children. In both protein-calorie malnutrition groups, the mean RAIUmax was significantly decreased by comparison with the mean normal RAIUmax (P less than 0.01). In protein-calorie malnutrition children, the RAIU curve reached intermediate values ranging from subnormal to about nearly half the normal. Thyroid clearance was early depressed and in some cases, dropped to values as low as one tenth of the normal mean (P less than 0.001), reflecting a severe thyroid involution. There is a high correlation between the RAIUmax and thyroid clearance values (r = 0.95); the regression line is defined by the equation Y = 1.12X + 17.08. Both functional parameters of thyroid activity appear to be mainly lowered in relation to the duration of protein deficiency.
分别采用口服和静脉注射放射性碘131I的方法，对两组各12名蛋白质-热量营养不良儿童进行甲状腺功能评估。静脉注射组儿童在24小时内放射性碘摄取量（RAIUmax）达到峰值，而口服组儿童则在48小时后才达到峰值。与正常RAIUmax均值相比，两个蛋白质-热量营养不良组的平均RAIUmax均显著降低（P<0.01）。蛋白质-热量营养不良儿童的RAIU曲线达到介于低于正常到接近正常一半之间的中间值。甲状腺清除率早期下降，在某些情况下，降至低至正常均值十分之一的值（P<0.001），反映出严重的甲状腺萎缩。RAIUmax与甲状腺清除率值之间存在高度相关性（r = 0.95）；回归线由方程Y = 1.12X + 17.08确定。甲状腺活动的这两个功能参数似乎主要与蛋白质缺乏的持续时间有关而降低。
