• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[检测青霉素类抗生素注射制剂的无菌性]

[Testing the sterility of injection preparations of penicillin series antibiotics].

作者信息

Chaĭkovskaia S M, Braginskaia P S, Tochenaia N P, Grigor'eva V M, Klimova N E

出版信息

Antibiotiki. 1978 Feb;23(2):171-3.

PMID:415660
Abstract

The efficiency of 3 variants of the method for determination of microbial flora was compared on the injection preparation of potassium benzylpenicillin artificially infected with Staph. aureus 209P and the spores of Bac. subtilis ATCC 6633 in different doses and with different amounts of the preparation in the vials. The procedure of the preparation dissolution in the vial with the thioglycol medium containing penicillinase proved to be most effective. The microbe detection amounted to 100 per cent. The procedure was less labour- and time-consuming since addition of penicillinase to each vial with the thioglycol medium was excluded. The risk of the medium occasional infection with microbial flora during the assay was decreased.

摘要

在人工感染金黄色葡萄球菌209P和不同剂量枯草芽孢杆菌ATCC 6633孢子且小瓶中制剂含量不同的苄星青霉素注射制剂上,比较了3种测定微生物菌群方法的效率。在含有青霉素酶的巯基乙酸盐培养基的小瓶中溶解制剂的程序被证明是最有效的。微生物检测率达100%。该程序省时省力,因为无需向每个含有巯基乙酸盐培养基的小瓶中添加青霉素酶。测定期间培养基偶尔被微生物菌群污染的风险降低。

相似文献

1
[Testing the sterility of injection preparations of penicillin series antibiotics].[检测青霉素类抗生素注射制剂的无菌性]
Antibiotiki. 1978 Feb;23(2):171-3.
2
[Comparison of the efficacy of 3 methods of testing for the sterility of eye ointments with antibiotics].[三种含抗生素眼膏无菌检查方法的效果比较]
Antibiotiki. 1976 Feb;21(2):118-22.
3
[Characteristics of determining the microbial contamination of penicillin series antibiotic powders and tablets].[青霉素类抗生素粉针剂及片剂微生物污染测定的特点]
Antibiotiki. 1977 Mar;22(3):208-11.
4
[Method of membrane filtration for determining the sterility and microbial contamination of antibiotics].[用于测定抗生素无菌性和微生物污染的膜过滤法]
Antibiotiki. 1977;22(2):113-7.
5
[In vitro activity and resistance behavior of the penicillins against Staph. aureus].[青霉素对金黄色葡萄球菌的体外活性及耐药行为]
Fortschr Med. 1982 Sep 9;100(34):1577-8.
6
[Regularities of the induction of enzyme synthesis by penicillin age-producing cultures of Staph. aureus, Bac. cereus 569, Bac. subtilis].[青霉素对金黄色葡萄球菌、蜡样芽孢杆菌569、枯草芽孢杆菌产酶培养物诱导酶合成的规律]
Antibiotiki. 1966 Oct;11(10):924-33.
7
Effects of beta-lactamase inhibitors on Staphylococcus aureus susceptibility to penicillin G and penicillinase-resistant penicillins.β-内酰胺酶抑制剂对金黄色葡萄球菌对青霉素G及耐青霉素酶青霉素敏感性的影响。
J Chemother. 1989 Jul;1(4 Suppl):344-5.
8
[Determination of penicillinase activity and its genetic location in penicillin resistant Staphylococcus aureus strains].[青霉素耐药金黄色葡萄球菌菌株中青霉素酶活性的测定及其基因定位]
Mikrobiyol Bul. 1977 Apr;11(2):267-78.
9
[Level of "internal" resistance of E. coli cultures to benyzlpenicillin].[大肠杆菌培养物对苄青霉素的“内在”抗性水平]
Antibiotiki. 1975 Mar;20(3):262-6.
10
[Pharmacokinetics of penicillins in the body of rats, including penetration into a granuloma, with repeated administration of the antibiotics and chymotrysin].[青霉素在大鼠体内的药代动力学,包括反复给予抗生素和胰凝乳蛋白酶后在肉芽肿中的渗透情况]
Antibiotiki. 1974 Nov;19(11):1012-7.