四环素、多西环素和米诺环素对甲氧西林敏感及耐药葡萄球菌的活性。
Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci.
作者信息
Minuth J N, Holmes T M, Musher D M
出版信息
Antimicrob Agents Chemother. 1974 Oct;6(4):411-4. doi: 10.1128/AAC.6.4.411.
Abstract
Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 mug/ml inhibited six of 13 strains and, at 3 mug/ml, 10 of 13 strains.
摘要
对四环素、多西环素和米诺环素针对甲氧西林敏感和耐药葡萄球菌分离株的抗菌活性进行了评估。在临床可达到的水平上，多西环素和米诺环素对甲氧西林敏感菌的活性均高于四环素。四环素和多西环素对耐甲氧西林葡萄球菌无活性，而米诺环素在2μg/ml时抑制了13株菌株中的6株，在3μg/ml时抑制了13株菌株中的10株。
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