厌氧细菌对米诺环素、多西环素和四环素的敏感性比较。
Comparative susceptibility of anaerobic bacteria to minocycline, doxycycline, and tetracycline.
作者信息
Chow A W, Patten V, Guze L B
出版信息
Antimicrob Agents Chemother. 1975 Jan;7(1):46-9. doi: 10.1128/AAC.7.1.46.
Abstract
The comparative susceptibility of 622 recent clinical isolates of anaerobic bacteria to minocycline, doxycycline, and tetracycline was determined by an agar-dilution technique. In addition to Bacteroides fragilis, a variety of other anaerobic bacteria was resistant to achievable blood concentrations of tetracycline (55% inhibited by 6.25 mug/ml) and doxycycline (58% inhibited by 2.5 mug/ml). In contrast, minocycline was significantly more active (P < 0.05) than both doxycycline and tetracycline, and 70% of strains were inhibited by achievable blood concentrations of this antibiotic (2.5 mug/ml). The enhanced activity of minocycline was particularly striking for Peptococcus asaccharolyticus, P. magnus, P. prevotii, Peptostreptococcus anaerobius, and Bacteroides melaninogenicus. Further evaluation of the clinical efficacy of minocycline against anaerobic infections is indicated.
摘要
采用琼脂稀释技术测定了622株近期临床分离的厌氧菌对米诺环素、多西环素和四环素的敏感性。除脆弱拟杆菌外，多种其他厌氧菌对四环素（6.25μg/ml抑制55%）和多西环素（2.5μg/ml抑制58%）可达到的血药浓度耐药。相比之下，米诺环素的活性显著高于多西环素和四环素（P<0.05），70%的菌株可被该抗生素可达到的血药浓度（2.5μg/ml）抑制。米诺环素对不解糖消化球菌、大消化球菌、普氏消化球菌、厌氧消化链球菌和产黑色素拟杆菌的增强活性尤为显著。有必要进一步评估米诺环素抗厌氧菌感染的临床疗效。
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本文引用的文献
1
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Antimicrob Agents Chemother. 1974 Jun;5(6):589-93. doi: 10.1128/AAC.5.6.589.
2
Metabolism and tissue distribution of radioisotopically labelled minocycline.放射性同位素标记米诺环素的代谢与组织分布
Toxicol Appl Pharmacol. 1967 Jul;11(1):171-83. doi: 10.1016/0041-008x(67)90036-1.
3
The susceptibility of bacteroides to the penicillins and cephalothin.拟杆菌对青霉素和头孢噻吩的敏感性。
Am J Med Sci. 1966 Apr;251(4):428-32. doi: 10.1097/00000441-196604000-00007.
4
Activity of minocycline and other tetracyclines against tetracycline-sensitive and -resistant staphylococci.米诺环素及其他四环素类药物对四环素敏感及耐药葡萄球菌的活性。
Proc Soc Exp Biol Med. 1971 Feb;136(2):479-81. doi: 10.3181/00379727-136-35292.
5
Standardized antimicrobial disc susceptibility testing of anaerobic bacteria. I. Susceptibility of Bacteroides fragilis to tetracycline.厌氧菌的标准化抗菌药敏试验。I. 脆弱拟杆菌对四环素的敏感性
Appl Microbiol. 1972 Feb;23(2):268-75. doi: 10.1128/am.23.2.268-275.1972.
6
[Clinical and laboratory research on minocycline].
Jpn J Antibiot. 1969 Dec;22(6):426-9.
7
Alpha-6-deoxyoxytetracycline. I. Some biological properties.
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1107-12. doi: 10.3181/00379727-122-31338.
8
Standardized single-disc method for antibiotic susceptibility testing of anaerobic bacteria.厌氧菌抗生素敏感性测试的标准化单碟法
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9
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10
Doxycycline blood levels in normal subjects after intravenous and oral administration.
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