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宋内志贺菌的氨苄西林耐药性

Ampicillin resistance of Shigella sonnei.

作者信息

Smith J T, Bremner D A, Datta N

出版信息

Antimicrob Agents Chemother. 1974 Oct;6(4):418-21. doi: 10.1128/AAC.6.4.418.

Abstract

The ampicillin resistance of clinical isolates of Shigella sonnei is due to beta-lactamase production. Two kinds of resistance are found: low level, nontransmissible; and high level, tranmissible. The nontransmissible type of resistance results from a chromosomal mutation which increases the production of a beta-lactamase that hydrolyses cephalosporins relatively rapidly and gives cephalothin resistance. The transmissible type of resistance is due to an R factor mediating the synthesis of a different beta-lactamase that does not significantly hydrolyze cephalosporins or confer cephalothin resistance. One clinical isolate is shown to possess simultaneously both these mechanisms of ampicillin resistance.

摘要

宋内志贺菌临床分离株对氨苄西林的耐药性是由于产生β-内酰胺酶所致。发现了两种耐药类型:低水平、不可传递的;以及高水平、可传递的。不可传递型耐药是由染色体突变引起的,该突变增加了一种β-内酰胺酶的产生,这种酶能相对快速地水解头孢菌素并导致对头孢噻吩耐药。可传递型耐药是由于一种R因子介导合成了一种不同的β-内酰胺酶,这种酶不会显著水解头孢菌素或导致对头孢噻吩耐药。有一株临床分离株被证明同时具有这两种氨苄西林耐药机制。

相似文献

1
Ampicillin resistance of Shigella sonnei.宋内志贺菌的氨苄西林耐药性
Antimicrob Agents Chemother. 1974 Oct;6(4):418-21. doi: 10.1128/AAC.6.4.418.
4
Antibiotic resistance in Shigella mediated by R factors.
J Infect Dis. 1971 May;123(5):477-84. doi: 10.1093/infdis/123.5.477.
5
Beta-lactamase activity in Shigella sonnei.宋内志贺菌中的β-内酰胺酶活性
Antimicrob Agents Chemother. 1976 May;9(5):776-9. doi: 10.1128/AAC.9.5.776.

本文引用的文献

2
The ampicillin resistance of Shigella sonnei: its epidemiological value.
Mon Bull Minist Health Public Health Lab Serv. 1966 Dec;25:278-81.
4
R-factor gene expression gram-negative bacteria.R因子基因在革兰氏阴性菌中的表达。
J Gen Microbiol. 1969 Jan;55(1):109-20. doi: 10.1099/00221287-55-1-109.
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R factors from Proteus rettgeri.来自雷氏变形杆菌的R因子。
J Gen Microbiol. 1972 Oct;72(3):543-52. doi: 10.1099/00221287-72-3-543.
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Antibiotic resistance of Shigella sonnei.宋内志贺菌的抗生素耐药性
Lancet. 1970 Dec 5;2(7684):1157-9. doi: 10.1016/s0140-6736(70)90341-7.

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