质粒决定的β-内酰胺酶与大肠杆菌的染色体β-内酰胺酶无法区分。
Plasmid-determined beta-lactamase indistinguishable from the chromosomal beta-lactamase of Escherichia coli.
作者信息
Bobrowski M M, Matthew M, Barth P T, Datta N, Grinter N J, Jacob A E, Kontomichalou P, Dale J W, Smith J T
出版信息
J Bacteriol. 1976 Jan;125(1):149-57. doi: 10.1128/jb.125.1.149-157.1976.
Abstract
A plasmid, derived from a naturally occurring strain of Proteus mirabilis, conferred resistance to cephalosporins, apparently mediated by a beta-lactamase indistinguishable from that determined by the chromosomal gene of Escherichia coli K-12. There was evidence for a recombination event between the wild-type plasmid and a defective F factor (Fsp) in the Escherichia coli K-12 culture in which it was stored.
摘要
一种源自奇异变形杆菌自然菌株的质粒赋予了对头孢菌素的抗性，这种抗性显然是由一种β-内酰胺酶介导的，该酶与大肠杆菌K-12染色体基因所决定的β-内酰胺酶无法区分。有证据表明，在保存该质粒的大肠杆菌K-12培养物中，野生型质粒与缺陷型F因子（Fsp）之间发生了重组事件。
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