R因子决定的β-内酰胺酶的分子特异性：与质粒相容性的相关性。
Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility.
作者信息
Hedges R W, Datta N, Kontomichalou P, Smith J T
出版信息
J Bacteriol. 1974 Jan;117(1):56-62. doi: 10.1128/jb.117.1.56-62.1974.
Abstract
Beta (beta)-lactamases determined by 29 ampicillin resistance plasmids could be divided into two types. One, TEM-type, was very uniform with respect to substrate specificity but heterogeneous in absolute levels of beta-lactamase activity. The TEM-type beta-lactamase was determined by R factors of compatibility groups FII, Ialpha, Iepsilon, N, C, A, T, W, P, L, and X, and by prophage phi Amp. The other type, characterized by the ability to hydrolyze oxacillin, was less common, showed lower absolute levels of activity, and was heterogeneous as regards substrate specificities. Oxacillin-hydrolyzing beta-lactamases were determined by R factors of compatibility groups FI, Ialpha, N, C, and O.
摘要
由29个氨苄西林抗性质粒所决定的β-内酰胺酶可分为两种类型。一种是TEM型，其底物特异性非常一致，但β-内酰胺酶活性的绝对水平存在异质性。TEM型β-内酰胺酶由相容性群FII、Iα、Iε、N、C、A、T、W、P、L和X的R因子以及原噬菌体φAmp所决定。另一种类型的特征是能够水解苯唑西林，这种类型较少见，其活性的绝对水平较低，并且在底物特异性方面存在异质性。水解苯唑西林的β-内酰胺酶由相容性群FI、Iα、N、C和O的R因子所决定。
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