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分离的胰岛中核苷磷酸化酶活性及肌苷刺激的胰岛素分泌的种属差异。

A species difference in nucleoside phosphorylase activity and inosine-stimulated insulin secretion in isolated islets of Langerhans.

作者信息

Campbell I L, Taylor K W

出版信息

Biochem J. 1977 Dec 15;168(3):591-3. doi: 10.1042/bj1680591.

DOI:10.1042/bj1680591
PMID:415735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1183812/
Abstract

Inosine is a potent simulant of insulin release from rat but not from rabbit islets of Langerhans. Further investigation showed that nucleoside phosphorylase activity is exceptionally low in rabbit islets. The ability of inosine to promote insulin release seems to be related to islet nucleoside phosphorylase activity, which can display marked species differences.

摘要

肌苷是大鼠胰岛胰岛素释放的有效刺激物，但不是兔胰岛的。进一步研究表明，兔胰岛中的核苷磷酸化酶活性极低。肌苷促进胰岛素释放的能力似乎与胰岛核苷磷酸化酶活性有关，而该活性存在明显的物种差异。

相似文献

1
A species difference in nucleoside phosphorylase activity and inosine-stimulated insulin secretion in isolated islets of Langerhans.分离的胰岛中核苷磷酸化酶活性及肌苷刺激的胰岛素分泌的种属差异。
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引用本文的文献

1
Inosine metabolism in the rat.大鼠体内的肌苷代谢
Biochem J. 1982 Dec 15;208(3):839-44. doi: 10.1042/bj2080839.
2
Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism.腺苷、2-脱氧腺苷和N6-苯基异丙基腺苷对大鼠胰岛功能和代谢的影响。
Biochem J. 1982 Jun 15;204(3):689-96. doi: 10.1042/bj2040689.
3
Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells.
Pflugers Arch. 1987 Nov;410(4-5):457-63. doi: 10.1007/BF00586525.
4
Opposite effects of starvation on oxidation of [14C]adenosine and adenosine-induced insulin release by isolated mouse pancreatic islets.饥饿对[14C]腺苷氧化及离体小鼠胰岛腺苷诱导的胰岛素释放的相反作用。
Biochem J. 1978 Nov 15;176(2):619-21. doi: 10.1042/bj1760619.
5
Species variation in the islets of Langerhans.
Diabetologia. 1979 Jan;16(1):1-4. doi: 10.1007/BF00423142.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Probable role of propionate and butyrate in control of insulin secretion in sheep.丙酸和丁酸在绵羊胰岛素分泌调控中的可能作用。
Am J Physiol. 1967 Apr;212(4):756-64. doi: 10.1152/ajplegacy.1967.212.4.756.
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Plasma insulin response to intravenously administered xylitol in dogs.犬静脉注射木糖醇后的血浆胰岛素反应。
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The pentose cycle and insulin release in mouse pancreatic islets.小鼠胰岛中的戊糖循环与胰岛素释放
Biochem J. 1972 Feb;126(3):525-32. doi: 10.1042/bj1260525.
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Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitro.钾离子与体外培养的胰岛分泌胰岛素的关系。
Biochem J. 1968 Jun;108(1):17-24. doi: 10.1042/bj1080017.
6
The effect of acetoacetate on plasma insulin concentration.乙酰乙酸对血浆胰岛素浓度的影响。
Biochem J. 1971 Nov;125(2):541-4. doi: 10.1042/bj1250541.
7
Adenosine and the regulation of insulin secretion by isolated rat islets of Langerhans.腺苷与大鼠离体胰岛胰岛素分泌的调节
Biochem J. 1977 May 15;164(2):409-13. doi: 10.1042/bj1640409.
8
Stimulation of proinsulin biosynthesis by purine-ribonucleosides and D-ribose.嘌呤核糖核苷和D-核糖对胰岛素原生物合成的刺激作用。
Endocrinology. 1977 Apr;100(4):923-7. doi: 10.1210/endo-100-4-923.
9
Inosine-stimulated insulin release and metabolism of inosine in isolated mouse pancreatic islets.肌苷刺激的分离小鼠胰岛中胰岛素释放及肌苷代谢
Biochem J. 1976 Aug 15;158(2):335-40. doi: 10.1042/bj1580335.