Wilson A E, Domino E F
Biomed Mass Spectrom. 1978 Feb;5(2):112-16. doi: 10.1002/bms.1200050203.
Phencyclidine was determined by gas chromatography selected ion monitoring in six dogs and seven monkeys. Aliquots of venous blood were taken over 4 h in the monkey after 1.1 mg kg-1 and over 24 h in the dog after 1.0 mg kg-1 of phencyclidine i.v. Pentadeuterated phencyclidine was used as the internal standard. In the electron impact mode the most abundant fragments in the mass spectrum of phencyclidine were m/e 91 and 200, and 96 and 205 in the [2H5]phencyclidine spectrum. These fragments were used to quantitate the amount of phencyclidine present. In both species, a complex exponential decline of plasma phencyclidine was found in most animals that fit a two compartment open model. In monkeys, the mean half-life (beta phase) was 2.36 h and in the dog it was 2.86 h. Compared with the monkey, the dog considerable emergence delirium. The two species had rather different pharmacokinetics which may be relevant to the observed differences in degree of anesthesia and recovery.
通过气相色谱选择离子监测法对6只狗和7只猴子体内的苯环利定进行了测定。静脉注射1.1毫克/千克苯环利定后，在猴子身上于4小时内采集多份静脉血样；静脉注射1.0毫克/千克苯环利定后，在狗身上于24小时内采集多份静脉血样。使用五氘代苯环利定作为内标。在电子轰击模式下，苯环利定质谱中最丰富的碎片是m/e 91和200，而在[2H5]苯环利定质谱中是96和205。这些碎片用于定量苯环利定的含量。在这两个物种中，大多数动物的血浆苯环利定呈现复杂的指数下降，符合二室开放模型。在猴子中，平均半衰期（β相）为2.36小时，在狗中为2.86小时。与猴子相比，狗出现了明显的谵妄。这两个物种的药代动力学有相当大的差异，这可能与观察到的麻醉程度和恢复差异有关。
