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补体灭活对大鼠迟发型超敏反应中结合抗原的影响。

The effect of decomplementation on delayed-type hypersensitive reactions to a conjugated antigen in rats.

作者信息

Neveu T, Biozzi G

出版信息

Immunology. 1965 Oct;9(4):303-9.

PMID:4158582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423600/
Abstract

A method has been described for quantitative measurement of the intensity of cutaneous delayed hypersensitive reactions in rats. This method is based on the measurement of the weight of skin infiltration at the site of cutaneous reaction. decomplementation of rats with antigen—antibody complexes or aggregated γ-globulin is accompanied by a decrease in delayed hypersensitivity responsiveness. When the level of serum complement is reduced by 90 per cent delayed hypersensitive reactions are completely suppressed. The results presented, although suggestive, do not provide a definite proof of the role of complement in the development of delayed hypersensitive reactions in the skin.

摘要

已经描述了一种定量测量大鼠皮肤迟发型超敏反应强度的方法。该方法基于测量皮肤反应部位的皮肤浸润重量。用抗原-抗体复合物或聚集的γ球蛋白使大鼠补体失活会伴随着迟发型超敏反应性的降低。当血清补体水平降低90%时，迟发型超敏反应被完全抑制。所呈现的结果虽然具有启发性，但并未提供补体在皮肤迟发型超敏反应发生中作用的确切证据。

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本文引用的文献

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Parallel Studies of Complement and Blood Coagulation XIV. In Tuberculin Shock.补体与血液凝固的平行研究十四。结核菌素休克。
Can J Comp Med Vet Sci. 1954 Jun;18(6):197-206.
2
[Technique of obtaining blood samples from small laboratory animals by puncture of ophthalmic plexus].[通过穿刺眼丛从小型实验动物获取血样的技术]
C R Seances Soc Biol Fil. 1951 Oct;145(19-20):1465-6.
3
[SUPPRESSION OF DELAYED HYPERSENSITIVITY BY THE EXTIRPATION OF REGIONAL LYMPH NODES].[通过切除局部淋巴结抑制迟发型超敏反应]
Int Arch Allergy Appl Immunol. 1963;23:140-9.
4
The use of specific "lymphocyte" antisera to inhibit hypersensitive reactions of the "delayed" type.使用特异性“淋巴细胞”抗血清抑制“迟发型”超敏反应。
J Exp Med. 1961 Dec 1;114(6):997-1022. doi: 10.1084/jem.114.6.997.
5
Activity of mouse complement.小鼠补体的活性
J Immunol. 1962 Dec;89:861-7.
6
Properties of guinea pig 7S antibodies. III. Identification of antibodies involved in complement fixation and hemolysis.豚鼠7S抗体的特性。III. 补体结合和溶血相关抗体的鉴定。
J Exp Med. 1963 Jun 1;117(6):965-81. doi: 10.1084/jem.117.6.965.
7
Delayed cutaneous reactions in the rat.大鼠的迟发性皮肤反应。
J Immunol. 1962 Oct;89:496-504.
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Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis.豚鼠7S抗体的特性。II. 被动皮肤过敏反应和全身性过敏反应中相关抗体的鉴定。
J Exp Med. 1963 Jun 1;117(6):951-64. doi: 10.1084/jem.117.6.951.
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Studies on the effect of complement on anaphylaxis in the mouse.关于补体对小鼠过敏反应影响的研究。
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