家兔淋巴细胞的体外研究。IV. 抗独特型血清诱导新生兔淋巴细胞向淋巴细胞供体血清中不存在的父本IgG独特型发生母细胞转化。
Studies on rabbit lymphocytes in vitro. IV. Blast transformation of the lymphocytes from newborn rabbits induced by antiallotype serum to a paternal IgG allotype not present in the serum of the lymphocyte donors.
作者信息
Sell S, Gell P G
出版信息
J Exp Med. 1965 Nov 1;122(5):923-8. doi: 10.1084/jem.122.5.923.
Abstract
Lymphocytes from the peripheral blood of newborn rabbits heterozygous for IgG allotypes As4 and As5, or As5 and As6, obtained at an age when only the maternal allotypic determinants are detectable in the serum, may be stimulated in vitro to transform into "blast" cells with antiallotype sera directed against the determinants contolled both by the maternal and by the paternal chromosomes. This result rules out the possibility that allotypic specificity is conferred upon lymphocytes by environmental IgG and suggests that the lymphocytes of newborn rabbits have the potential to synthesize IgG determinants either in the form of intact IgG molecules or constituent polypeptide chains.
摘要
从新生兔外周血中获取的淋巴细胞，这些新生兔对于IgG同种异型As4和As5或As5和As6是杂合子，在血清中仅能检测到母体同种异型决定簇的年龄时获取，用针对由母体和父体染色体控制的决定簇的抗同种异型血清在体外刺激，可转化为“母细胞”。这一结果排除了环境IgG赋予淋巴细胞同种异型特异性的可能性，并表明新生兔的淋巴细胞有潜力以完整IgG分子或组成多肽链的形式合成IgG决定簇。
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ALLOTYPIC SPECIFICITIES OF A- AND B-CHAINS OF RABBIT GAMMA GLOBULIN.兔γ球蛋白A链和B链的同种异型特异性
Science. 1964 Jul 24;145(3630):403-5. doi: 10.1126/science.145.3630.403.
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IMMUNOCHEMICAL ANALYSIS OF RABBIT GAMMA-G.OBULIN ALLOTYPES.兔γ球蛋白同种异型的免疫化学分析
Nature. 1963 Nov 16;200:653-4. doi: 10.1038/200653a0.
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Effect of maternal isoantibodies on the quantitative expression of two allelic genes controlling gamma-globulin allotypic specificities.母体同种抗体对控制γ-球蛋白同种异型特异性的两个等位基因定量表达的影响。
Nature. 1962 Aug 18;195:677-80. doi: 10.1038/195677a0.
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A notation for allotypy.同种异型的一种表示法。
Nature. 1962 Aug 25;195:785-6. doi: 10.1038/195785a0.
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The nature of the immunologic inadequacy of neonatal rabbits. II. Antibody formation by neonatal splenic cells transferred to adult recipients.新生兔免疫缺陷的本质。II. 转移至成年受体的新生脾细胞的抗体形成
J Exp Med. 1959 Jul 1;110(1):139-46. doi: 10.1084/jem.110.1.139.
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Studies on rabbit lymphocytes in vitro. II. Induction of blast transformation with antisera to six IgG allotypes and summation with mixtures of antisera to different allotypes.兔淋巴细胞的体外研究。II. 用针对六种IgG同种异型的抗血清诱导母细胞转化以及不同同种异型抗血清混合物的累加作用
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8
Studies on rabbit lymphocytes in vitro. 3. Proteins, RNA, and DNA synthesis by lymphocyte cultures after stimulation with phytohaemagglutinin, with staphylococcal filtrate, with antiallotype serum, and with heterologous antiserum to rabbit whole serum.兔淋巴细胞的体外研究。3. 用植物血凝素、葡萄球菌滤液、抗同种异型血清以及兔全血清的异种抗血清刺激后淋巴细胞培养物中的蛋白质、RNA和DNA合成。
J Exp Med. 1965 Oct 1;122(4):823-39. doi: 10.1084/jem.122.4.823.
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