参与免疫反应的细胞。VII. 使用同种异型标记，证明注射正常同种异体骨髓细胞和绵羊红细胞的受照射兔的抗辐射细胞形成抗体。
Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes.
作者信息
Richter M, Abdou N I
出版信息
J Exp Med. 1969 Jun 1;129(6):1261-73. doi: 10.1084/jem.129.6.1261.
Abstract
Bone marrow cells obtained from rabbits of one allotype were injected into irradiated rabbits of a different allotype. The recipients were also injected with sheep red blood cells, and their spleen cells were tested for plaque-forming capacity 7 days later. Spleen cells of all recipients gave large numbers of plaques as did spleen cells incubated with antiserum, directed toward donor allotype. However, incubation of the recipient spleen cells with antiserum directed toward recipient allotype completely suppressed plaque formation. These results demonstrate that antibody-formation in irradiated recipients of transferred lymphoid cells is a property of the recipient animal and that the antibody-forming cell is relatively irradiation-resistant. It was also demonstrated that only viable normal bone marrow cells are capable of transferring antibody-forming capacity to irradiated recipient rabbits. Neither sonicates nor heat-killed preparations of normal rabbit bone marrow cells possessed this capacity.
摘要
从一种同种异型的兔子身上获取骨髓细胞，将其注射到不同同种异型且经过辐照的兔子体内。给受体兔子也注射绵羊红细胞，7天后检测其脾细胞的形成噬斑能力。所有受体的脾细胞都产生了大量噬斑，与用针对供体同种异型的抗血清孵育的脾细胞一样。然而，用针对受体同种异型的抗血清孵育受体脾细胞会完全抑制噬斑形成。这些结果表明，在接受转移淋巴细胞的辐照受体中抗体形成是受体动物的一种特性，并且抗体形成细胞相对抗辐照。还证明只有活的正常骨髓细胞能够将抗体形成能力转移给经辐照的受体兔子。正常兔骨髓细胞的超声裂解物和热灭活制剂均不具备这种能力。
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Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes.参与免疫反应的细胞。VII. 使用同种异型标记，证明注射正常同种异体骨髓细胞和绵羊红细胞的受照射兔的抗辐射细胞形成抗体。
J Exp Med. 1969 Jun 1;129(6):1261-73. doi: 10.1084/jem.129.6.1261.
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Cells involved in the immune response. VI. The immune response to red blood cells in irradiated rabbits after administration of normal, primed, or immune allogeneic rabbit bone marrow cells.参与免疫反应的细胞。VI. 给受照射的兔子注射正常、致敏或免疫的同种异体兔骨髓细胞后对红细胞的免疫反应。
J Exp Med. 1969 Apr 1;129(4):757-74. doi: 10.1084/jem.129.4.757.
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Cells involved in the immune response. X. The transfer of antibody-forming capacity to irradiated rabbits by antigen-reactive cells isolated from normal allogeneic rabbit bone marrow after passage through antigen-sensitized glass bead columns.参与免疫反应的细胞。十、经抗原致敏玻璃珠柱处理后从正常同种异体兔骨髓中分离出的抗原反应性细胞将抗体形成能力转移给受辐照兔。
J Exp Med. 1969 Jul 1;130(1):141-63. doi: 10.1084/jem.130.1.141.
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Immunological memory in mice. II. Cell interactions in the secondary immune response studies by means of immunoglobulin allotype markers.小鼠的免疫记忆。II. 通过免疫球蛋白同种异型标记研究二次免疫应答中的细胞相互作用。
J Exp Med. 1970 Jun 1;131(6):1109-20. doi: 10.1084/jem.131.6.1109.
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Cells involved in the immune response. XI. Identification of the antigen-reactive cell as the tolerant cell in the immunologically tolerant rabbit.参与免疫反应的细胞。十一、在免疫耐受兔中确定抗原反应性细胞为耐受细胞。
J Exp Med. 1969 Jul 1;130(1):165-84. doi: 10.1084/jem.130.1.165.
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Active suppression of immunoglobulin allotype synthesis. II. Transfer of suppressing factor with spleen cells.免疫球蛋白同种异型合成的主动抑制。II. 抑制因子与脾细胞的转移。
J Exp Med. 1972 May 1;135(5):1163-76. doi: 10.1084/jem.135.5.1163.
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Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
J Exp Med. 1968 Oct 1;128(4):821-37. doi: 10.1084/jem.128.4.821.
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Cells involved in the immune response, IX. Depletion from the normal rabbit bone marrow of antigen-reactive cells directed toward human peripheral leukocytes.参与免疫反应的细胞，IX. 从正常兔骨髓中清除针对人外周血白细胞的抗原反应性细胞。
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1136-43. doi: 10.1073/pnas.63.4.1136.
引用本文的文献
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J Exp Med. 1970 Nov;132(5):926-40. doi: 10.1084/jem.132.5.926.
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In vitro induction of specific unresponsiveness of immunologically reactive, normal bone marrow cells.体外诱导免疫活性正常骨髓细胞的特异性无反应性。
J Exp Med. 1970 Jan 1;131(1):149-64. doi: 10.1084/jem.131.1.149.
3
Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits.参与免疫反应的细胞。8. 正常成年兔经照射后抗原反应性细胞的丧失与再现及免疫反应性之间的关系。
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Cells involved in the immune response. XII. The differing responses of normal rabbit lymphoid cells to phytohemagglutinin, goat anti-rabbit immunoglobulin antiserum and allogeneic and xenogeneic lymphocytes.参与免疫反应的细胞。十二、正常兔淋巴细胞对植物血凝素、山羊抗兔免疫球蛋白抗血清以及同种异体和异种淋巴细胞的不同反应。
J Exp Med. 1969 Nov 1;130(5):1187-208. doi: 10.1084/jem.130.5.1187.
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Cells involved in the immune response. 13. The nature of the cellular interactions relating antibody formation and immunologic tolerance: a unified hypothesis.参与免疫反应的细胞。13. 与抗体形成和免疫耐受相关的细胞相互作用的本质：一个统一的假说。
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Proc Natl Acad Sci U S A. 1969 Aug;63(4):1136-43. doi: 10.1073/pnas.63.4.1136.
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Time-dependent synergism of rats spleen and bone marrow cells.大鼠脾脏和骨髓细胞的时间依赖性协同作用。
Immunology. 1972 May;22(5):901-5.
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Cells involved in cell-mediated and transplantation immunity in the rabbit. I. The noninvolvement of the bone marrow antigen reactive cell in the transplant rejection reaction.兔细胞介导免疫和移植免疫中的细胞。I. 骨髓抗原反应性细胞不参与移植排斥反应。
Proc Natl Acad Sci U S A. 1970 Jan;65(1):70-3. doi: 10.1073/pnas.65.1.70.
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Cells involved in the immune response. X. The transfer of antibody-forming capacity to irradiated rabbits by antigen-reactive cells isolated from normal allogeneic rabbit bone marrow after passage through antigen-sensitized glass bead columns.参与免疫反应的细胞。十、经抗原致敏玻璃珠柱处理后从正常同种异体兔骨髓中分离出的抗原反应性细胞将抗体形成能力转移给受辐照兔。
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A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.体外诱导初次免疫反应所需的三细胞相互作用。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):542-7. doi: 10.1073/pnas.61.2.542.
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STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM.家兔淋巴细胞的体外研究。I. 用抗独特型血清刺激母细胞转化
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IMMUNOCHEMICAL IDENTIFICATION AND GENETICS OF RABBIT GAMMA-GLOBULIN ALLOTYPES.兔γ-球蛋白同种异型的免疫化学鉴定与遗传学
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Plaque formation in agar by single antibody-producing cells.单个产生抗体的细胞在琼脂中形成菌斑。
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Antibody formation in vitro.体外抗体形成。
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A notation for allotypy.同种异型的一种表示法。
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Iso-antigens of rabbit gamma-globulin.兔γ球蛋白的同种抗原
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Allotypy of rabbit serum proteins. II. Relationships between various allotypes: their common antigenic specificity, their distribution in a sample population; genetic implications.兔血清蛋白的同种异型。II. 各种同种异型之间的关系：它们共同的抗原特异性、在样本群体中的分布；遗传学意义。
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Two antigenically different gamma-globulins in domestic rabbits revealed by isoprecipitins.等沉淀素揭示家兔体内两种抗原性不同的γ-球蛋白。
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Serum groups in rabbits.家兔的血清型
Immunology. 1959 Jan;2(1):84-92.
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