新生兔免疫缺陷的本质。II. 转移至成年受体的新生脾细胞的抗体形成
The nature of the immunologic inadequacy of neonatal rabbits. II. Antibody formation by neonatal splenic cells transferred to adult recipients.
作者信息
DIXON F J, WEIGLE W O
出版信息
J Exp Med. 1959 Jul 1;110(1):139-46. doi: 10.1084/jem.110.1.139.
Abstract
It has been shown that cells from neonatal rabbits are capable of producing considerable amounts of antibody after exposure to antigen in vitro and transfer to x-radiated adult recipients. This suggests that the immunological inadequacy of these neonates is not dependent primarily upon the lack of cells capable of antibody formation. Both in vitro sensitized neonatal lymphoid cells and in vivo sensitized adult lymphoid cells made much more antibody after transfer to x-rayed adult recipients than to neonatal recipients. Possible reasons for and significance of these observations are pointed out in the discussion.
摘要
已经表明，新生兔的细胞在体外接触抗原后能够产生大量抗体，并转移给经X射线照射的成年受体。这表明这些新生儿的免疫缺陷并非主要取决于缺乏能够形成抗体的细胞。无论是体外致敏的新生淋巴细胞还是体内致敏的成年淋巴细胞，转移到经X射线照射的成年受体后产生的抗体都比转移到新生受体后产生的抗体多得多。讨论中指出了这些观察结果的可能原因和意义。
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