Belshe R B, Richardson L S, London W T, Sly D L, Lorfeld J H, Camargo E, Prevar D A, Chanock R M
J Med Virol. 1977;1(3):157-62. doi: 10.1002/jmv.1890010302.
Four species of nonhuman primates were inoculated intranasally with 10(3.1) to 10(3.7) plaque forming units (pfu) of respiratory syncytial (RS) virus. Adults squirrel monkeys and newborn rhesus monkeys became infected and shed small quantities (peak titer 10(2.0) pfu/ml of nasopharyngeal swab specimen) of virus, but illness did not develop. Infant cebus monkeys aged 2 months became infected, shed 10(2.3) to 10(3.8) pfu/ml of nasopharyngeal swab specimen, but did not become ill. Chimpanzees aged 15 to 18 months shed a large quantity of virus, up to 10(6.0) pfu/ml of nasopharyngeal swab specimen and developed an upper respiratory illness. Chimpanzees are proposed as a possible animal model for future study of the immunopathology of RS virus disease and for in vivo evaluation of attenuated live virus vaccine candidates.
将10(3.1)至10(3.7)个呼吸道合胞（RS）病毒空斑形成单位（pfu）经鼻内接种给四种非人灵长类动物。成年松鼠猴和新生恒河猴受到感染并排出少量病毒（鼻咽拭子标本的峰值滴度为10(2.0)pfu/ml），但未发病。2个月大的婴猴受到感染，排出的鼻咽拭子标本病毒量为10(2.3)至10(3.8)pfu/ml，但未发病。15至18个月大的黑猩猩排出大量病毒，鼻咽拭子标本中病毒量高达10(6.0)pfu/ml，并患上了上呼吸道疾病。黑猩猩被提议作为未来研究RS病毒疾病免疫病理学以及体内评估减毒活病毒候选疫苗的可能动物模型。
