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类风湿因子与天然人γ-G球蛋白反应的超速离心研究。

Ultracentrifugal studies of the reactions of rheumatoid factor with native human gamma-G-globulin.

作者信息

Normansell D E, Stanworth D R

出版信息

Immunology. 1966 Jun;10(6):527-33.

PMID:4161806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423730/
Abstract

Analytical ultracentrifugation has been employed in a study of the effect of pH on the dissociation of the 22S complexes formed between isolated rheumatoid factor and native human γG-globulin (prepared from autologous and isologous rheumatoid sera and from normal sera). The results indicate that rheumatoid factor has equal avidity for each of the γG-globulins tested irrespective of their source. The possibility that native human γG-globulin is a `haptenic' form of aggregated γG-globulin is discussed.

摘要

分析超速离心法已被用于一项研究，该研究旨在探讨pH值对分离出的类风湿因子与天然人γG球蛋白（由自体和同种异体类风湿血清以及正常血清制备）形成的22S复合物解离的影响。结果表明，类风湿因子对所测试的每种γG球蛋白具有相同的亲和力，而不论其来源如何。文中讨论了天然人γG球蛋白是聚集γG球蛋白的“半抗原”形式的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/1423730/4924a83ac1ae/immunology00425-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/1423730/4924a83ac1ae/immunology00425-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3532/1423730/4924a83ac1ae/immunology00425-0035-a.jpg

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Ultracentrifugal studies of the reactions of rheumatoid factor with native human gamma-G-globulin.类风湿因子与天然人γ-G球蛋白反应的超速离心研究。
Immunology. 1966 Jun;10(6):527-33.
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引用本文的文献

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The metabolism of autologous IgM and 19S rheumatoid factor in rheumatoid arthritis.类风湿关节炎中自体IgM和19S类风湿因子的代谢
Clin Exp Immunol. 1969 May;4(5):537-53.
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Hypercatabolism of normal IgG; an unexplained immunoglobulin abnormality in the connective tissue diseases.正常IgG的高分解代谢；结缔组织病中一种不明原因的免疫球蛋白异常。
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Acta Pathol Microbiol Scand. 1965;64:103-18. doi: 10.1111/apm.1965.64.1.103.
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VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.免疫应答过程中抗体亲和力的变化
Biochemistry. 1964 Jul;3:996-1008. doi: 10.1021/bi00895a027.
3
STUDIES OF THE ANTIBODY NATURE OF THE RHEUMATOID FACTOR. REACTION OF THE RHEUMATOID FACTOR WITH HUMAN SPECIFIC PRECIPITATES AND WITH NATIVE HUMAN GAMMA GLOBULIN.
Clin Exp Immunol. 1968 Sep;3(7):671-90.
4
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5
A monoclonal IgM protein with antibody-like activity for human albumin.一种对人白蛋白具有抗体样活性的单克隆IgM蛋白。
J Clin Invest. 1974 Mar;53(3):932-40. doi: 10.1172/JCI107634.
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A possible immunochemical explanation for pregnancy associated remissions in rheumatoid arthritis?类风湿关节炎妊娠相关缓解的一种可能的免疫化学解释？
Ann Rheum Dis. 1988 Feb;47(2):89-90. doi: 10.1136/ard.47.2.89.
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