某些类风湿性滑膜炎积液中存在聚集的γ-G球蛋白。
Presence of aggregated gamma-G-globulin in certain rheumatoid synovial effusions.
作者信息
Hannestad K
出版信息
Clin Exp Immunol. 1967 Jul;2(4):511-29.
Abstract
A precipitin reaction occurred between rheumatoid arthritis sera with high titre rheumatoid factor (RF) and certain rheumatoid synovial effusions. The precipitating factor in the sera was shown to be γM-type RF, reacting mainly with human γG-globulin. The precipitating component of synovial effusions was structurally altered, γG-globulin sedimenting much faster than native γG-globulin by density gradient ultracentrifugation. Following exposure to increasing hydrogen ion concentrations, an increasing amount of the RF-precipitating γG-globulin attained a slower sedimentation rate. Evidence for the presence of this altered γG-globulin was given, indicating that it may represent a stimulus for RF production.
摘要
高滴度类风湿因子（RF）的类风湿性关节炎血清与某些类风湿性滑膜积液之间发生了沉淀反应。血清中的沉淀因子被证明是γM型RF，主要与人γG球蛋白反应。滑膜积液的沉淀成分在结构上发生了改变，通过密度梯度超速离心法，γG球蛋白的沉降速度比天然γG球蛋白快得多。随着氢离子浓度的增加，越来越多的RF沉淀γG球蛋白沉降速度变慢。文中给出了这种改变的γG球蛋白存在的证据，表明它可能是RF产生的一种刺激因素。
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本文引用的文献
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