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1
Bacteriostatic effects of horse sera and serum fractions on Clostridium welchii Type A, and the abolition of bacteriostasis by iron salts.马血清及血清组分对A型魏氏梭菌的抑菌作用,以及铁盐对抑菌作用的消除。
Immunology. 1967 Mar;12(3):285-301.
2
Iron compounds and resistance to infection. Further experiments with Clostridium welchii type A in vivo and in vitro.铁化合物与抗感染能力。A型韦氏梭菌在体内和体外的进一步实验。
Immunology. 1970 Oct;19(4):521-38.
3
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4
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[Studies with the lecitho-vitellin test on changes in the immune titer of the serum of anti-perfringens serum horses].[用卵磷脂-卵黄磷蛋白试验研究抗产气荚膜梭菌血清马匹血清免疫效价的变化]
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引用本文的文献

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3
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4
The bacteriostatic effect of serum on Pasteurella septica and its abolition by iron compounds.血清对败血巴氏杆菌的抑菌作用及其被铁化合物消除的情况。
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5
The effect of iron compounds on the virulence of Escherichia coli for guinea-pigs.铁化合物对大肠杆菌致豚鼠毒性的影响。
Immunology. 1968 Oct;15(4):581-8.
6
The abolition of the protective effect of Clostridium welchii type A antiserum by ferric iron.A型魏氏梭菌抗血清的保护作用被三价铁消除。
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7
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9
Iron compounds and resistance to infection. Further experiments with Clostridium welchii type A in vivo and in vitro.铁化合物与抗感染能力。A型韦氏梭菌在体内和体外的进一步实验。
Immunology. 1970 Oct;19(4):521-38.
10
The critical role of iron in some clinical infections.铁在某些临床感染中的关键作用。
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本文引用的文献

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RAW HEN EGG WHITE AND THE ROLE OF IRON IN GROWTH INHIBITION OF SHIGELLA DYSENTERIAE, STAPHYLOCOCCUS AUREUS, ESCHERICHIA COLI AND SACCHAROMYCES CEREVISIAE.生鸡蛋清以及铁在抑制痢疾志贺氏菌、金黄色葡萄球菌、大肠杆菌和酿酒酵母生长中的作用。
Science. 1944 Jul 7;100(2584):14-5. doi: 10.1126/science.100.2584.14.
2
An Iron-binding Component in Human Blood Plasma.人血浆中的一种铁结合成分。
Science. 1946 Oct 11;104(2702):340-1. doi: 10.1126/science.104.2702.340.
3
Glucose metabolism of Clostridium perfringens: existence of metallo-aldolase.产气荚膜梭菌的葡萄糖代谢:金属醛缩酶的存在
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Nutrition of animal cells in tissue culture; initial studies on a synthetic medium.组织培养中动物细胞的营养;对合成培养基的初步研究。
Proc Soc Exp Biol Med. 1950 Jan;73(1):1-8. doi: 10.3181/00379727-73-17557.
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Relation of transferrin to serum bacteriostatic activity in agammaglobulinemic and other patients.无丙种球蛋白血症患者及其他患者中转铁蛋白与血清抑菌活性的关系。
Am J Med Sci. 1962 Sep;244:334-6. doi: 10.1097/00000441-196209000-00009.
6
GROWTH OF STAPHYLOCOCCUS AUREUS IN MEDIA OF RESTRICTED AND UNRESTRICTED INORGANIC IRON AVAILABILITY.金黄色葡萄球菌在无机铁可利用性受限和不受限培养基中的生长情况
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SEPARATION AND PURIFICATION OF BETA-LYSIN FROM NORMAL SERUM.从正常血清中分离和纯化β-溶素
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8
REVERSAL BY FERRIC IRON OF SERUM INHIBITION OF RESPIRATION AND GROWTH OF BACILLUS SUBTILIS.铁离子对血清抑制枯草芽孢杆菌呼吸和生长的作用的逆转
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9
BACTERIOSTATIC EFFECTS OF SPECIFIC ANTISERUM ON CLOSTRIDIUM WELCHII TYPE A. THE ROLE OF EH AND PH OF THE MEDIUM.特异性抗血清对A型魏氏梭菌的抑菌作用。培养基的氧化还原电位(EH)和pH值的作用。
J Gen Microbiol. 1964 May;35:175-82. doi: 10.1099/00221287-35-2-175.
10
A METHOD FOR THE CONTROL OF EH AND PH DURING BACTERIAL GROWTH.一种在细菌生长过程中控制氧化还原电位(EH)和酸碱度(pH)的方法。
J Gen Microbiol. 1964 May;35:169-74. doi: 10.1099/00221287-35-2-169.

马血清及血清组分对A型魏氏梭菌的抑菌作用,以及铁盐对抑菌作用的消除。

Bacteriostatic effects of horse sera and serum fractions on Clostridium welchii Type A, and the abolition of bacteriostasis by iron salts.

作者信息

Rogers H J

出版信息

Immunology. 1967 Mar;12(3):285-301.

PMID:4164032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409119/
Abstract

Under a variety of conditions of concentration, Eh, and pH, horse anti- serum and normal horse serum exerted similar bacteriostatic effects against Type A. Ferric iron abolished the bacteriostatic effect when added during the first 2 hours of incubation at Eh+60 mV. Ferrous iron abolished the bacteriostatic effect when added after 3 hours. Ferric iron abolished the bacteriostatic effect at—140 mV. A mixture consisting of horse β- and γ-globulins together with human transferrin exerted a bacteriostatic effect similar to that of whole serum. This system responded in the same way as whole serum to the addition of iron. A mixture of horse β- and γ-globulins exerted an immediate bactericidal effect which could not be prevented by ferric iron.

摘要

在多种浓度、氧化还原电位(Eh)和pH条件下,马抗血清和正常马血清对A型菌具有相似的抑菌作用。在Eh为+60 mV的条件下孵育的最初2小时内添加三价铁会消除抑菌作用。在3小时后添加二价铁会消除抑菌作用。在-140 mV时三价铁会消除抑菌作用。由马β球蛋白和γ球蛋白以及人转铁蛋白组成的混合物产生的抑菌作用与全血清相似。该系统对添加铁的反应与全血清相同。马β球蛋白和γ球蛋白的混合物产生即时杀菌作用,且这种作用不能被三价铁阻止。