马血清及血清组分对A型魏氏梭菌的抑菌作用，以及铁盐对抑菌作用的消除。
Bacteriostatic effects of horse sera and serum fractions on Clostridium welchii Type A, and the abolition of bacteriostasis by iron salts.
作者信息
Rogers H J
出版信息
Immunology. 1967 Mar;12(3):285-301.
Abstract
Under a variety of conditions of concentration, Eh, and pH, horse anti- serum and normal horse serum exerted similar bacteriostatic effects against Type A. Ferric iron abolished the bacteriostatic effect when added during the first 2 hours of incubation at Eh+60 mV. Ferrous iron abolished the bacteriostatic effect when added after 3 hours. Ferric iron abolished the bacteriostatic effect at—140 mV. A mixture consisting of horse β- and γ-globulins together with human transferrin exerted a bacteriostatic effect similar to that of whole serum. This system responded in the same way as whole serum to the addition of iron. A mixture of horse β- and γ-globulins exerted an immediate bactericidal effect which could not be prevented by ferric iron.
摘要
在多种浓度、氧化还原电位（Eh）和pH条件下，马抗血清和正常马血清对A型菌具有相似的抑菌作用。在Eh为+60 mV的条件下孵育的最初2小时内添加三价铁会消除抑菌作用。在3小时后添加二价铁会消除抑菌作用。在-140 mV时三价铁会消除抑菌作用。由马β球蛋白和γ球蛋白以及人转铁蛋白组成的混合物产生的抑菌作用与全血清相似。该系统对添加铁的反应与全血清相同。马β球蛋白和γ球蛋白的混合物产生即时杀菌作用，且这种作用不能被三价铁阻止。
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