铁化合物对大肠杆菌致豚鼠毒性的影响。
The effect of iron compounds on the virulence of Escherichia coli for guinea-pigs.
作者信息
Bullen J J, Leigh L C, Rogers H J
出版信息
Immunology. 1968 Oct;15(4):581-8.
Abstract
Ferric ammonium citrate, haematin hydrochloride, lysed guinea-pig red cells and crystalline human haemoglobin greatly enhanced the virulence of 0111/B4/H2 when injected intraperitoneally into normal guinea-pigs. The viable counts of in the peritoneal fluid of normal guinea-pigs given a sub-lethal infection were very variable and the bacteria eventually disappeared. In lethal infections in animals treated with iron compounds the bacteria grew extremely rapidly and death occurred when the counts reached 10–10/ml of peritoneal fluid. It is suggested that the mechanisms underlying non-specific immunity of guinea-pigs to may not be dissimilar to those involved in passive immunity to Type A in guinea-pigs, and in passive immunity to in mice.
摘要
柠檬酸铁铵、盐酸血红素、裂解的豚鼠红细胞和结晶人血红蛋白腹腔注射到正常豚鼠体内时，可大大增强0111/B4/H2的毒力。给正常豚鼠进行亚致死感染后，其腹腔液中的活菌数变化很大，细菌最终消失。在用铁化合物处理的动物的致死性感染中，细菌生长极快，当腹腔液中菌数达到10⁹-10¹⁰/ml时动物死亡。有人认为，豚鼠对该菌非特异性免疫的潜在机制可能与豚鼠对A型菌的被动免疫以及小鼠对该菌的被动免疫所涉及的机制并无不同。
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