A型魏氏梭菌抗血清的保护作用被三价铁消除。
The abolition of the protective effect of Clostridium welchii type A antiserum by ferric iron.
作者信息
Bullen J J, Cushnie G H, Rogers H J
出版信息
Immunology. 1967 Mar;12(3):303-12.
Abstract
Intravenous injection of ferric ammonium citrate equivalent to 5 mg iron/kg abolished the protective effect of antiserum in guinea-pigs infected with type A. In animals not given iron there was an abrupt cessation of growth 4–5 hours after infection. In those given iron bacterial growth was continuous and the animals died in 12–24 hours. In both of the animals there was always an excess of alpha antitoxin in the plasma and tissues. Injection of iron did not interfere with phagocytosis of . Iron abolished the protective effect of antiserum up to 6 hours after infection. It had no effect when given 8 hours after infection or later.
摘要
静脉注射相当于5毫克铁/千克的柠檬酸铁铵可消除抗血清对感染A型病毒的豚鼠的保护作用。在未给予铁剂的动物中，感染后4至5小时生长突然停止。在给予铁剂的动物中，细菌持续生长，动物在12至24小时内死亡。在这两种动物的血浆和组织中始终存在过量的α抗毒素。铁的注射并不干扰对……的吞噬作用。铁在感染后6小时内消除了抗血清的保护作用。在感染8小时后或更晚给予时则没有效果。
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