滑膜积液中的类风湿因子：局部产生与消耗
Rheumatoid factor in synovial effusions: local production and consumption.
作者信息
Hannestad K, Mellbye O J
出版信息
Clin Exp Immunol. 1967 Jul;2(4):501-9.
The ratio of synovial fluid γM-type rheumatoid factor (RF) to serum RF was compared with the ratio for two other γM-antibodies (trypsin- and periodate agglutinin) and total γM-globulin content in thirteen patients with rheumatoid arthritis. In one case, the ratio for RF was higher than the ratios for the other γM-globulins and declined after synovectomy, indicating that a significant amount of RF in the synovial fluid was derived from locally produced RF. In three cases, the ratio for RF was lower than the other γM-globulin ratios, indicating local consumption or inhibition of RF in the joint. It was postulated that this phenomenon was due to some form of aggregated γG-globulin. In nine cases, the ratio for RF was equal or almost equal to the ratios for the other γM-globulins, indicating that the synovial fluid RF in these cases was mainly delivered from the circulation.
对13例类风湿性关节炎患者的滑液γM型类风湿因子（RF）与血清RF的比率，与另外两种γM抗体（胰蛋白酶和高碘酸盐凝集素）的比率以及总γM球蛋白含量进行了比较。在1例患者中，RF的比率高于其他γM球蛋白的比率，并且在滑膜切除术后下降，这表明滑液中大量的RF源自局部产生的RF。在3例患者中，RF的比率低于其他γM球蛋白的比率，表明关节中RF存在局部消耗或抑制。据推测，这种现象是由于某种形式的聚集γG球蛋白所致。在9例患者中，RF的比率等于或几乎等于其他γM球蛋白的比率，表明在这些病例中滑液RF主要来自循环系统。
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