Nagai B, Matsuda I, Kondo T, Taniguchi N, Arashima S, Mitsuyama T, Oka Y, Honma M
Eur J Pediatr. 1979 Nov;132(3):161-8. doi: 10.1007/BF00442432.
Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase and red cell carbonic anhydrase were measured in 37 selected patients receiving anticonvulsants. Patients with metabolic acidosis showed a high incidence of hypocalcemia with increased alkaline phosphatase and a significant reduction of carbonic anhydrase-B activity. High iPTH levels were found in 13 patients, but this was not correlated with acid-base balance status. Anticonvulsant drugs seemed to inactive carbonic anhydrase-B activity. Metabolic acidosis might be one of the factors causing a disturbance of calcium metabolism in these patients.
对37例服用抗惊厥药的特定患者进行了血液pH值、碳酸氢盐、二氧化碳分压、血清钙、碱性磷酸酶和红细胞碳酸酐酶的检测。代谢性酸中毒患者低钙血症发生率较高，碱性磷酸酶升高，碳酸酐酶-B活性显著降低。13例患者甲状旁腺激素水平升高，但这与酸碱平衡状态无关。抗惊厥药物似乎使碳酸酐酶-B活性失活。代谢性酸中毒可能是导致这些患者钙代谢紊乱的因素之一。
