Frick O L, Nye W, Raffel S
Immunology. 1968 Apr;14(4):563-8.
The question whether a univalent antigen may suffice for the elicitation of anaphylactic reactions is the subject of this study. We previously reported that certain univalent alpha substituted ε-DNP-lysine compounds can elicit such reactions. Evidence on this question has been extended to include the use of a number of aliphatic as well as a cyclic α substituent in ε-DNP-lysine. The haptens most active in eliciting PCA responses were the 8 and 10 C α-acyl derivatives. A cyclic acyl compound (α-hexahydrobenzoyl-ε-DNP-lysine) was inactive. A hypothesis is advanced to account for the release of histamine from the cells of sensitive animals by simple (1:1) complexing of antigen with antibody, based upon the structures and activities of the compounds tested.
单价抗原是否足以引发过敏反应这一问题是本研究的主题。我们之前报道过某些单价α取代的ε-二硝基苯赖氨酸化合物能够引发此类反应。关于这个问题的证据已扩展到包括在ε-二硝基苯赖氨酸中使用多种脂肪族以及环状α取代基。在引发被动皮肤过敏反应（PCA）中最具活性的半抗原有8个和10个碳的α-酰基衍生物。一种环状酰基化合物（α-六氢苯甲酰基-ε-二硝基苯赖氨酸）无活性。基于所测试化合物的结构和活性，提出了一个假说，即通过抗原与抗体的简单（1:1）络合作用，使敏感动物细胞释放组胺。
