二硝基苯基-聚-L-赖氨酸在反应型和无反应型豚鼠中的竞争效应。
The competitive effect of DNP-poly-L-lysine in responder and non-responder guinea pigs.
作者信息
Ben-Efraim S, Liacopoulos P
出版信息
Immunology. 1969 May;16(5):573-80.
Abstract
The synthetic antigen DNP—p(Lys), which it is known to induce an immune response only in a certain percentage of randomly bred guinea-pigs, inhibited the immune response towards p(Tyr, Glu, Ala) and p(Tyr, Glu) synthetic antigens in all the guinea-pigs tested. The extent of the competitive effect was related to the quantity of DNP—p(Lys) injected. The hapten moiety DNP—mono-lysine, had no inhibitory effect, while the p(Lys) carrier interfered with the response to p(Tyr, Glu), although to a lesser extent than did the complete conjugate.
摘要
已知合成抗原二硝基苯 - 聚赖氨酸（DNP—p(Lys)）仅在一定比例的随机繁殖豚鼠中诱导免疫反应，它在所有测试的豚鼠中抑制了对聚（酪氨酸、谷氨酸、丙氨酸）（p(Tyr, Glu, Ala)）和聚（酪氨酸、谷氨酸）（p(Tyr, Glu)）合成抗原的免疫反应。竞争效应的程度与注射的DNP—p(Lys)的量有关。半抗原部分二硝基苯 - 单赖氨酸没有抑制作用，而聚赖氨酸载体干扰了对聚（酪氨酸、谷氨酸）的反应，尽管程度比完整偶联物小。
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