Bollgren I, Vaclavinkova V, Hurvell B, Bergqvist G
Br Med J. 1978 May 20;1(6123):1314-7. doi: 10.1136/bmj.1.6123.1314.
Seventy-two pregnant and 88 non-pregnant women were examined to see whether the periurethral region had been colonised with group B streptococci (Streptococcus agalactiae), enterococci, and Gram-negative rods belonging to the Enterobacteriaeceae. A semi-quantitative method was used for periurethral sampling, and paired urethral swabs were also collected to compare the isolation rates of group B streptococci from the two sites and with the two sampling methods. A higher isolation rate was found with periurethral sampling. Most specimens showed no or scanty growth of Gram-negative rods. Pregnancy was often associated with heavy growth of enterococci. Sampling performed during menstruation and while oral contraceptives were being used produced high isolation rates of group B streptococci. These results seem to suggest that the periurethral area might protect against genital colonisation with group B streptococci as it does against urinary tract infection and that hormonal factors influence the carriage of these organisms.
对72名孕妇和88名非孕妇进行了检查，以确定尿道周围区域是否被B族链球菌（无乳链球菌）、肠球菌以及属于肠杆菌科的革兰氏阴性杆菌定植。采用半定量方法对尿道周围进行采样，同时还采集了配对的尿道拭子，以比较两种采样方法从两个部位分离出B族链球菌的比率。尿道周围采样的分离率更高。大多数标本显示革兰氏阴性杆菌生长极少或无生长。怀孕常与肠球菌大量生长有关。在月经期间和使用口服避孕药时进行采样，B族链球菌的分离率很高。这些结果似乎表明，尿道周围区域可能像预防尿路感染一样预防B族链球菌的生殖道定植，并且激素因素会影响这些微生物的携带情况。
