Brumfitt W, Gargan R A, Hamilton-Miller J M
Lancet. 1987 Apr 11;1(8537):824-6. doi: 10.1016/s0140-6736(87)91606-0.
The periurethral enterobacterial flora was identified before infective episodes in 56 patients with recurrent urinary infection. There were 91 episodes of infection, with colonisation by aerobic gram-negative bacilli in 60. In only 31 (34%) episodes were patients colonised with the infective strain. In 31 episodes there was no colonisation of the perineum and in 29 there was heterologous colonisation. In another group of 54 women investigated during an enterobacterial infection of the urine there was colonisation with the infecting organism in 55 (86%) of 64 episodes; in 2 there was no colonisation; and 7 (11%) were associated with a heterologous strain. Women who have recurrent urinary infections are susceptible to perineal and periurethral colonisation with gram-negative bacteria but the infection need not be with the colonising enterobacteria.
在56例复发性尿路感染患者的感染发作前，对其尿道周围肠道菌群进行了鉴定。共发生91次感染发作，其中60次有氧革兰氏阴性杆菌定植。仅31次（34%）发作中患者被感染菌株定植。31次发作中会阴部未发生定植，29次发作中有异源定植。在另一组54名女性中，在尿液肠道细菌感染期间进行调查，64次发作中有55次（86%）被感染生物体定植；2次未发生定植；7次（11%）与异源菌株有关。复发性尿路感染的女性易发生革兰氏阴性菌会阴部和尿道周围定植，但感染不一定由定植的肠道杆菌引起。
