抗菌药物治疗后尿道周围微生物群的变化。
Changes in periurethral microflora after antimicrobial drugs.
作者信息
Lidefelt K J, Bollgren I, Nord C E
机构信息
Department of Paediatrics, Karolinska Institute, Sachs' Children's Hospital, Stockholm, Sweden.
出版信息
Arch Dis Child. 1991 Jun;66(6):683-5. doi: 10.1136/adc.66.6.683.
The periurethral flora was examined in 18 girls by use of a quantitative sampling method before, during, and three weeks after treatment with antibiotics for upper respiratory tract infections. Eight girls received amoxicillin. In five of them the anaerobic flora showed a reduction in total counts and in numbers of different species, and all eight girls got a heavy colonisation with enterobacteria during treatment. Three weeks after treatment the anaerobic and aerobic flora had reversed to the pretreatment composition. In 10 girls treated with trimethoprim-sulphamethoxazole the anaerobic flora remained unaffected and no enterobacterial overgrowth was registered during the study period. We propose that antibiotics could be one among several factors involved in the pathogenesis of urinary tract infection, by suppression of the anaerobic microflora and promotion of the colonisation with enterobacteria.
采用定量采样方法，对18名女童在上呼吸道感染接受抗生素治疗前、治疗期间及治疗后三周的尿道周围菌群进行了检查。8名女童接受阿莫西林治疗。其中5名女童的厌氧菌群总数及不同菌种数量减少，且在治疗期间所有8名女童均出现肠道杆菌大量定植。治疗三周后，厌氧菌群需氧菌群恢复至治疗前的组成。10名接受甲氧苄啶 - 磺胺甲恶唑治疗的女童，厌氧菌群未受影响，且在研究期间未发现肠道杆菌过度生长。我们认为，抗生素可能是参与尿路感染发病机制的多种因素之一，它通过抑制厌氧菌群并促进肠道杆菌定植发挥作用。
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