Bourgeois J P, Betz H, Changuex J P
C R Acad Hebd Seances Acad Sci D. 1978 Mar 13;286(10):773-6.
Chronic paralysis of Chick embryos by the cholinergic antagonist flaxedil blocks the subsynaptic accumulation of acetylcholinesterase but not the formation of acetylcholine receptor cluster. Flaxedil paralysis also causes an increase of the total muscle content of acetylcholine receptor without altering the half-life of the receptor protein. The spontaneous activity of the embryon therefore "shuts off" the synthesis of extrasynpatic acetylcholine receptor.
胆碱能拮抗剂三碘季铵酚对鸡胚的慢性麻痹作用会阻断乙酰胆碱酯酶在突触下的积聚，但不会阻断乙酰胆碱受体簇的形成。三碘季铵酚麻痹还会导致乙酰胆碱受体的肌肉总含量增加，而不会改变受体蛋白的半衰期。因此，胚胎的自发活动“关闭”了突触外乙酰胆碱受体的合成。
