人淋巴细胞的转化：同源α球蛋白的抑制作用
Transformation of human lymphocytes: inhibition by homologous alpha globulin.
作者信息
Cooperband S R, Bondevik H, Schmid K, Mannick J A
出版信息
Science. 1968 Mar 15;159(3820):1243-4. doi: 10.1126/science.159.3820.1243.
PMID:4179930
Abstract
An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulating immunosuppressant factor which prevents lymphoid cell proliferation.
摘要
通过柱色谱法从正常人血浆中制备的α球蛋白组分可阻止同源淋巴细胞转化以及DNA的刺激，还能抑制由植物血凝素和特定抗原诱导的蛋白质合成。这些观察结果支持了存在一种正常循环免疫抑制因子可阻止淋巴细胞增殖这一概念。
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