同种异体淋巴细胞相互作用的体外分析。II. B细胞活化过程中I区对B细胞衍生的H-2限制性同种异体效应因子及其受体活性的控制。
In vitro analysis of allogeneic lymphocyte interaction. II. I-region control of the activity of a B-cell-derived H-2-restricted allogeneic effect factor and its receptor during B-cell activation.
作者信息
Delovitch T L, Biggin J, Fung F Y
出版信息
J Exp Med. 1978 Apr 1;147(4):1198-212. doi: 10.1084/jem.147.4.1198.
Abstract
A genetically restricted allogeneic effect factor (AEF) derived from a mixed lymphocyte culture reaction between Ia-negative activated responder cells and irradiated T-cell-depleted stimulator cells was characterized. Restricted AEF is a B-cell-derived soluble helper factor which consists in part of Ia antigens controlled by the I-A subregion of the stimulator haplotype; additional control by the I-B, I-E, and I-C subregions, although unlikely, could not be excluded. This factor helps B cells of only its own haplotype or of haplotypes which carry an I-A and/or I-B subregion identity. Unprimed as well as hapten-primed Ia-positive B cells express a receptor for restricted AEF. The results indicate that the B-cell receptor for AEF is determined by the I-A subregion. Both restricted AEF and its receptor may therefore be products of the same I-region gene(s). The data are compatible with the hypothesis that the AEF Ia antigens serve as a second signal required for B-cell activation to IgG antibody production.
摘要
对一种基因受限的同种异体效应因子（AEF）进行了表征，该因子源自Ia阴性活化应答细胞与经辐照的T细胞耗竭刺激细胞之间的混合淋巴细胞培养反应。受限AEF是一种B细胞衍生的可溶性辅助因子，其部分由刺激单倍型的I-A亚区控制的Ia抗原组成；虽然I-B、I-E和I-C亚区的额外控制不太可能，但也不能排除。该因子仅帮助其自身单倍型或携带I-A和/或I-B亚区同一性的单倍型的B细胞。未致敏以及半抗原致敏的Ia阳性B细胞均表达受限AEF的受体。结果表明，AEF的B细胞受体由I-A亚区决定。因此，受限AEF及其受体可能是同一I区基因的产物。这些数据与以下假设相符：AEF Ia抗原作为B细胞激活产生IgG抗体所需的第二个信号。
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