一个新的在T细胞上表达并定位于I-C亚区的淋巴细胞激活决定簇基因座。
A new lymphocyte-activating determinant locus expressed on T cells, and mapping in I-C subregion.
作者信息
Okuda K, David C S
出版信息
J Exp Med. 1978 Apr 1;147(4):1028-37. doi: 10.1084/jem.147.4.1028.
Abstract
A new lymphocyte-activating determinant (Lad) locus expressed on T cells was identified, mapping in the I-C subregions of H-2k and H-2d haplotypes. The mixed lymphocyte reaction stimulation could be inhibited by anti-Ia sera made in strains incompatible for this chromosomal segment. Experiments with purified lymphocyte cell populations suggested that this Lad locus was expressed on T cells. Further, only purified T cells were able to remove the inhibiting activity from the anti-Ia sera. I-C subregion gene(s) seem to code for products selectively expressed on a subpopulation of T cells.
摘要
一个在T细胞上表达的新的淋巴细胞激活决定簇（Lad）基因座被鉴定出来，它定位于H-2k和H-2d单倍型的I-C亚区。这种混合淋巴细胞反应刺激可被针对该染色体片段不相容的品系制备的抗Ia血清所抑制。对纯化的淋巴细胞群体进行的实验表明，这个Lad基因座在T细胞上表达。此外，只有纯化的T细胞能够消除抗Ia血清中的抑制活性。I-C亚区基因似乎编码在T细胞亚群上选择性表达的产物。
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