致敏淋巴细胞的分离半抗原结合受体。III. T细胞受体独特型限制的证据。
Isolated hapten-binding receptors of sensitized lymphocytes. III. Evidence for idiotypic restriction of T-cell receptors.
作者信息
Krawinkel U, Cramer M, Melchers I, Imanishi-Kari T, Rajewsky K
出版信息
J Exp Med. 1978 May 1;147(5):1341-7. doi: 10.1084/jem.147.5.1341.
Abstract
The primary antibody response of C57BL/6 mice to the 4-hydroxy-3-nitrophenylacetyl (NP) hapten is restricted to antibody molecules expressing the NPb idiotype. This idiotype is a genetic marker for V genes in the heavy chain linkage group. In the secondary response, the frequency of NPb idiotype-positive molecules within the antibody population drops to very low values. Accordingly, isolated NP binding receptors from NP-sensitized B lymphocytes are largely devoid of this idiotype. In contrast, the NPb idiotype is expressed on the majority of the receptor fractions which we consider T-cell derived. This finding suggests that the antigen receptors of T lymphocytes may be restricted to the expression of major (germ-line encoded?) heavy chain idiotypes.
摘要
C57BL/6小鼠对4-羟基-3-硝基苯乙酰（NP）半抗原的初次抗体反应仅限于表达NPb独特型的抗体分子。这种独特型是重链连锁群中V基因的遗传标记。在二次反应中，抗体群体中NPb独特型阳性分子的频率降至非常低的值。因此，从NP致敏的B淋巴细胞中分离出的NP结合受体在很大程度上缺乏这种独特型。相反，NPb独特型在我们认为是T细胞来源的大多数受体组分上表达。这一发现表明，T淋巴细胞的抗原受体可能仅限于主要（种系编码的？）重链独特型的表达。
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1
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2
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Nature. 1974 Jan 11;247(5436):104-6. doi: 10.1038/247104a0.
3
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4
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