3-甲基胆蒽诱导的小鼠肉瘤肿瘤特异性抗原的染色体定位
Chromosome assignment of the tumor-specific antigen of a 3-methylcholanthrene-induced mouse sarcoma.
作者信息
Pravtcheva D D, DeLeo A B, Ruddle F H, Old L J
出版信息
J Exp Med. 1981 Sep 1;154(3):964-77. doi: 10.1084/jem.154.3.964.
Abstract
Chemically induced sarcomas of inbred mice express antigens that are distinct and specific for each individual tumor. Chromosome assignment of tumor-specific antigens would help to elucidate the genetic basis of their diversity. Expression of the serologically defined Meth A sarcoma antigen is not suppressed in hybrid cells containing a complete foreign (Chinese hamster) genome. Chromosome and serologic analysis of microcell hybrids between Meth A sarcoma cells and Chinese hamster cells shows a clear correlation of Meth A antigen expression with the presence of the distal region of chromosome 12 (bands F1 and F2). Chromosome 16 may also be implicated. The significance of the close linkage of genes determining Meth A antigen expression with the immunoglobulin heavy chain gene cluster (on chromosome 12) and the lambda light chain genes (on chromosome 16) is discussed.
摘要
化学诱导的近交系小鼠肉瘤表达的抗原对于每个个体肿瘤而言都是独特且特异的。肿瘤特异性抗原的染色体定位将有助于阐明其多样性的遗传基础。血清学定义的Meth A肉瘤抗原在含有完整外源（中国仓鼠）基因组的杂交细胞中表达并未受到抑制。对Meth A肉瘤细胞与中国仓鼠细胞之间的微细胞杂交体进行染色体和血清学分析，结果显示Meth A抗原表达与12号染色体远端区域（F1和F2带）的存在有着明显的相关性。16号染色体可能也与之有关。本文讨论了决定Meth A抗原表达的基因与免疫球蛋白重链基因簇（位于12号染色体上）和λ轻链基因（位于16号染色体上）紧密连锁的意义。
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