致敏淋巴细胞的分离半抗原结合受体。II. 来自尼龙毛富集兔T淋巴细胞的受体缺乏免疫球蛋白恒定区的血清学决定簇，但带有A位点同种异型标记。
Isolated hapten-binding receptors of sensitized lymphocytes. II. Receptors from nylon wool-enriched rabbit T lymphocytes lack serological determinants of immunoglobulin constant domains but carry the A locus allotypic markers.
作者信息
Krawinkel U, Cramer M, Mage R G, Kelus A S, Rajewsky K
出版信息
J Exp Med. 1977 Sep 1;146(3):792-801. doi: 10.1084/jem.146.3.792.
Abstract
Hapten-binding receptor material was isolated from sensitized rabbit lymphocytes by a method described previously for murine receptor material. The material was separated into a fraction expressing immunoglobulin determinants (anti-Ig+ fraction) and a fraction lacking known class and type-specific determinants of Ig constant domains (anti-Ig- fraction). We present evidence in support of the notion that--in analogy to the mouse system--the anti-Ig+ fraction is B-cell-derived, whereas the anti-Ig- fraction originates from T lymphocytes. Receptors of the anti-Ig- phenotype are found to express a locus allotypic determinants and, thus, appear to carry variable portions of immunoglobulin heavy chains.
摘要
采用先前描述的用于分离鼠源受体物质的方法，从致敏兔淋巴细胞中分离出半抗原结合受体物质。该物质被分离为表达免疫球蛋白决定簇的部分（抗Ig+部分）和缺乏已知Ig恒定区类别和型特异性决定簇的部分（抗Ig-部分）。我们提供的证据支持这样一种观点，即类似于小鼠系统，抗Ig+部分来源于B细胞，而抗Ig-部分起源于T淋巴细胞。发现抗Ig-表型的受体表达一个基因座同种异型决定簇，因此似乎携带免疫球蛋白重链的可变部分。
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