Tritsch G L, Minowada J
J Natl Cancer Inst. 1978 Jun;60(6):1301-4. doi: 10.1093/jnci/60.6.1301.
Clear metabolic differences between T- and B-cells were demonstrated. Both adenosine deaminase (ADA) and nucleoside phosphorylase (NP) activities increased during logarithmic growth and then decreased in T-cells, but remained essentially constant during the growth cycle of B-cells. When these enzyme activities were examined in a number of T-cell, B-cell, and null cell lines, ADA activity was clearly higher in T-cells as compared to all others. With NP, the opposite appeared to be true, although the differences were much smaller and not statistically significant in all instances. No clear differences were found in the isoenzyme distributions of both enzymes in the various cell types.
T细胞和B细胞之间存在明显的代谢差异。在对数生长期，T细胞中的腺苷脱氨酶（ADA）和核苷磷酸化酶（NP）活性均升高，随后降低，但在B细胞的生长周期中基本保持恒定。当在多种T细胞、B细胞和裸细胞系中检测这些酶活性时，与所有其他细胞相比，T细胞中的ADA活性明显更高。对于NP，情况似乎相反，尽管差异要小得多，且并非在所有情况下都具有统计学意义。在不同细胞类型中，两种酶的同工酶分布未发现明显差异。
