Reaman G H, Blatt J, Poplack D G
Blood. 1981 Aug;58(2):330-2.
Activities of enzymes of the purine metabolic pathway, adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5'-nucleotidase (5'-N), were investigated in the lymphoblasts of a patient with B-cell acute lymphoblastic leukemia. These lymphoblasts exhibited increased ADA activity and diminished activities of both PNP and 5'N' as compared to normal lymphocytes as well as non-T, non-B leukemia cells. This enzymatic pattern is identical to that which has been described in T-cell leukemic lymphoblasts and differs from that which has been observed in the malignant cells of undifferentiated B-cell lymphomas. These data suggest that there is biochemical heterogeneity within the spectrum of B-cell malignancies. Furthermore, inhibitors of ADA may be of use in those B-cell lymphoid neoplasms that exhibit increased ADA activity.
对一名B细胞急性淋巴细胞白血病患者的淋巴母细胞中嘌呤代谢途径的酶活性进行了研究，这些酶包括腺苷脱氨酶（ADA）、嘌呤核苷磷酸化酶（PNP）和5'-核苷酸酶（5'-N）。与正常淋巴细胞以及非T、非B白血病细胞相比，这些淋巴母细胞表现出ADA活性增加，而PNP和5'-N活性降低。这种酶模式与在T细胞白血病淋巴母细胞中所描述的相同，与未分化B细胞淋巴瘤的恶性细胞中所观察到的不同。这些数据表明，B细胞恶性肿瘤谱内存在生化异质性。此外，ADA抑制剂可能对那些表现出ADA活性增加的B细胞淋巴样肿瘤有用。
