参与免疫反应的细胞。8. 正常成年兔经照射后抗原反应性细胞的丧失与再现及免疫反应性之间的关系。
Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits.
作者信息
Abdou N I, Rose B, Richter M
出版信息
J Exp Med. 1969 Oct 1;130(4):867-76. doi: 10.1084/jem.130.4.867.
Abstract
By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit.
摘要
通过适当的照射和细胞转移实验，观察到存活且具有免疫活性的抗原反应性细胞的存在与兔子免疫后产生反应的能力之间存在直接关联。接受全身800拉德照射的兔子无法引发体液免疫反应，它们也不拥有大量的抗原反应性细胞。直到能够检测到抗原反应性细胞时，才重新出现产生体液抗体的反应能力。这些结果有力地表明，有能力的抗原反应性细胞的存在是兔子成功诱导体液免疫反应所必需的。
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引用本文的文献
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本文引用的文献
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Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
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Plasma cell proliferation following whole body irradiation.全身照射后的浆细胞增殖
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THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.脊髓灰质炎病毒中和抗体的形成与特性。II. 19S和7S抗体的形成：持续合成、回忆反应及对X射线照射敏感性方面抗原剂量需求的差异
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Enhancement of antibody formation by whole body x-radiation.全身X线辐射增强抗体形成
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Plaque formation in agar by single antibody-producing cells.单个产生抗体的细胞在琼脂中形成菌斑。
Science. 1963 Apr 26;140(3565):405.
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Studies on whole-body x-irradiation effects on anaphylactic hypersensitivity in guinea pigs.豚鼠全身X线照射对过敏性超敏反应影响的研究。
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