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1
Cells involved in the immune response. 13. The nature of the cellular interactions relating antibody formation and immunologic tolerance: a unified hypothesis.参与免疫反应的细胞。13. 与抗体形成和免疫耐受相关的细胞相互作用的本质：一个统一的假说。
Proc Natl Acad Sci U S A. 1969 Sep;64(1):75-80. doi: 10.1073/pnas.64.1.75.
2
Cells involved in the immune response. XI. Identification of the antigen-reactive cell as the tolerant cell in the immunologically tolerant rabbit.参与免疫反应的细胞。十一、在免疫耐受兔中确定抗原反应性细胞为耐受细胞。
J Exp Med. 1969 Jul 1;130(1):165-84. doi: 10.1084/jem.130.1.165.
3
Studies on the mechanism of specific immunological unresponsiveness. II. Immunological properties of lymphoid cells from normal, immunized and immunologically unresponsive mice transferred into lethally irradiated recipients.特异性免疫无反应性机制的研究。II. 来自正常、免疫和免疫无反应小鼠的淋巴细胞转移至致死性照射受体后的免疫特性。
Z Immunitatsforsch Exp Klin Immunol. 1976 Mar;151(1-2):22-31.
4
Physiological aspects of cellular and humoral immunoreactions.细胞免疫反应和体液免疫反应的生理学方面。
Monatsschr Kinderheilkd (1902). 1972 Jun 5;120(6):197-201.
5
Cell-mediated immune responses. Report of a WHO scientific group.细胞介导的免疫反应。世界卫生组织科学小组报告。
World Health Organ Tech Rep Ser. 1969;423:7-61.
6
The nature of the immune response.免疫反应的本质。
Biochem Soc Symp. 1970;30:61-88.
7
Contact and delayed hypersensitivity in the mouse. 3. Depression of contact sensitivity by pre-treatment with antigen and the restoration of immune competence in tolerant mice by normal lymphoid and bone marrow cells.小鼠中的接触性和迟发性超敏反应。3. 抗原预处理对接触敏感性的抑制以及正常淋巴细胞和骨髓细胞对耐受小鼠免疫能力的恢复。
Immunology. 1970 Jan;18(1):99-106.
8
[Immunity, immune tolerance and immunosuppression].[免疫、免疫耐受与免疫抑制]
Allerg Asthma (Leipz). 1970;16(3):101-13.
9
[Comparison between the dynamics of antibody production in the spleen and in the bone marrow].[脾脏与骨髓中抗体产生动力学的比较]
Allerg Immunol (Leipz). 1973;19(2-4):185-8.
10
Cellular events in protein tolerant inbred rats. I. The fate of thoracic duct lymphocytes and memory cells during tolerance induction to human serum albumin.蛋白质耐受近交系大鼠的细胞事件。I. 诱导对人血清白蛋白耐受过程中胸导管淋巴细胞和记忆细胞的命运。
Eur J Immunol. 1973 May;3(5):259-67. doi: 10.1002/eji.1830030503.

引用本文的文献

1
Time Relationships Between Injection of Antigen and Adjuvant I. Adjuvancy of Bordetella pertussis Given at Various Times Before the Primary Antigenic Stimulus.抗原和佐剂注射时间的关系 I. 在初级抗原刺激之前的不同时间给予百日咳博德特氏菌作为佐剂的佐剂作用。
Infect Immun. 1970 Nov;2(5):590-600. doi: 10.1128/iai.2.5.590-600.1970.
2
Changes in the synthesis of antibiodies and non-specific immunoglobulins in the spleen perfused in vitro.体外灌注脾脏中抗体和非特异性免疫球蛋白合成的变化。
Immunology. 1971 Dec;21(6):915-24.
3
Time relationships between injection of antigen and adjuvant. 3. Adjuvancy of Bordetella pertussis given at various times after the primary antigenic stimulus.抗原与佐剂注射的时间关系。3. 在初次抗原刺激后不同时间给予百日咳博德特氏菌的佐剂效应。
Infect Immun. 1972 May;5(5):783-91. doi: 10.1128/iai.5.5.783-791.1972.
4
Cells involved in cell-mediated and transplantation immunity. II. A consideration of the functional identity of the cells involved in both humoral and cell-mediated immunity: a phylogenetic approach.参与细胞介导免疫和移植免疫的细胞。II. 关于体液免疫和细胞介导免疫中所涉及细胞功能一致性的探讨：一种系统发育学方法。
Proc Natl Acad Sci U S A. 1970 Aug;66(4):1127-35. doi: 10.1073/pnas.66.4.1127.
5
The secondary antibody response in tissue culture. IV. Studies of the in vivo and in vitro antigenicity of native, aggregate-free and aggregated human gamma globulin in rabbits.组织培养中的二次抗体反应。IV. 兔体内和体外天然、无聚集体和聚集的人γ球蛋白的抗原性研究。
Immunology. 1970 Jun;18(6):833-41.

本文引用的文献

1
A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.体外诱导初次免疫反应所需的三细胞相互作用。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):542-7. doi: 10.1073/pnas.61.2.542.
2
THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. I. PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO SINGLE AND MULTIPLE INJECTIONS OF ANTIGEN.大鼠对绵羊红细胞产生耐受性的机制。I. 对单次和多次注射抗原的噬斑形成细胞及抗体反应。
J Exp Med. 1965 May 1;121(5):671-81. doi: 10.1084/jem.121.5.671.
3
The histophysiology of the antibody response. I. Histogenesis of the plasma cell reaction in rabbit spleen.抗体反应的组织生理学。I. 兔脾脏浆细胞反应的组织发生
Lab Invest. 1963 Jan;12:106-18.
4
Role of macrophages in antibody production. Immune response to sheep red blood cells.巨噬细胞在抗体产生中的作用。对绵羊红细胞的免疫反应。
J Immunol. 1967 Oct;99(4):744-50.
5
The role of macrophages in the induction of antibody in x-irradiated animals.巨噬细胞在受X射线照射动物体内抗体诱导中的作用。
Immunology. 1967 Feb;12(2):197-206.
6
Macrophages from tolerant rabbits as mediators of a specific immunological response in vitro.来自耐受兔的巨噬细胞作为体外特异性免疫反应的介质。
Immunology. 1967 Feb;12(2):159-63.
7
The coexistence of antibody with antigen during immunological paralysis to BSA.在对牛血清白蛋白产生免疫麻痹期间抗体与抗原的共存。
Immunology. 1966 Dec;11(6):571-88.
8
The carriage of immunological memory by small lymphocytes in the rat.大鼠中小淋巴细胞的免疫记忆携带情况。
J Exp Med. 1966 Nov 1;124(5):1017-30. doi: 10.1084/jem.124.5.1017.
9
The immunogenic capacity of antigen taken up by peritoneal exudate cells.腹膜渗出细胞摄取的抗原的免疫原性能力。
Immunology. 1969 Jan;16(1):1-14.
10
Cells involved in the immune response. VI. The immune response to red blood cells in irradiated rabbits after administration of normal, primed, or immune allogeneic rabbit bone marrow cells.参与免疫反应的细胞。VI. 给受照射的兔子注射正常、致敏或免疫的同种异体兔骨髓细胞后对红细胞的免疫反应。
J Exp Med. 1969 Apr 1;129(4):757-74. doi: 10.1084/jem.129.4.757.

参与免疫反应的细胞。13. 与抗体形成和免疫耐受相关的细胞相互作用的本质：一个统一的假说。

Cells involved in the immune response. 13. The nature of the cellular interactions relating antibody formation and immunologic tolerance: a unified hypothesis.

作者信息

Richter M

出版信息

Proc Natl Acad Sci U S A. 1969 Sep;64(1):75-80. doi: 10.1073/pnas.64.1.75.

DOI:10.1073/pnas.64.1.75
PMID:5263025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC286128/
Abstract

The various cells and cell pathways involved in the induction of the primary humoral immune response have been discussed from the point of view of the unitary, as opposed to the multiple, pathway concept. The immunocompetent cells made unresponsive in the immunologically tolerant animal and the cells capable of responding with antibody formation were considered. It is concluded that there exist multiple cellular pathways through which the humoral immune response may be expressed.

摘要

从单一途径而非多途径概念的角度，讨论了参与初次体液免疫应答诱导的各种细胞和细胞途径。研究了在免疫耐受动物中变得无反应的免疫活性细胞以及能够产生抗体形成反应的细胞。得出的结论是，存在多种细胞途径，通过这些途径可以表达体液免疫应答。