Schlienger J L, Hasselman M, Imler M
Ann Endocrinol (Paris). 1978;39(1):75-6.
Serum concentrations of thyroid hormones and TSH response to TRH are studied in normal controls and in patients with liver cirrhosis. T3 levels are significantly diminished in the cirrhotic group while the mean total T4 concentration, the basal TSH and the magnitude of the peak response to TRH are similar in cirrhotic and control patients. However when the cirrhotic patients are separated in two groups according to the level of arterial ammonemia, it appears that the group with hyperammonemia (n = 10) has a significantly higher peak response than the control group. Since hyperammonemia is a wittness of hepatic encephalopathy it is suggested that TSH release or synthesis may be modified by this situation resulting from a cerebral accumulation of false neurotransmitters and a depletion of aminergic mediators.
在正常对照组和肝硬化患者中研究了甲状腺激素的血清浓度以及促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应。肝硬化组的三碘甲状腺原氨酸（T3）水平显著降低，而肝硬化患者和对照患者的平均总甲状腺素（T4）浓度、基础TSH以及对TRH的峰值反应幅度相似。然而，当根据动脉血氨水平将肝硬化患者分为两组时，高血氨组（n = 10）的峰值反应似乎显著高于对照组。由于高血氨是肝性脑病的一个指征，提示这种由假性神经递质的脑内蓄积和胺能介质耗竭导致的情况可能会改变TSH的释放或合成。
