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多发性硬化症中 HLA 抗原以及对麻疹和风疹病毒的抗体反应

HLA antigens and antibody responses to measles and rubella viruses in multiple sclerosis.

作者信息

Ilonen J, Herva E, Reunanen M, Panelius M, Meurman O, Arstila P, Tiilikainen A

出版信息

Acta Neurol Scand. 1977 Apr;55(4):299-309. doi: 10.1111/j.1600-0404.1977.tb05649.x.

Abstract

Twenty-four HLA-antigens coded by loci A and B were determined serologically for 60 multiple sclerosis patients from Northern Finland. Forty-five of the patients were also typed by mixed leucocyte culture reactivity for HLA-Dw2. The only statistically significant difference in antigen frequencies in these patients compared with those in controls was the decrease of HLA-A2 among patients. Measles and rubella antibody titres in patients with and without HLA-Dw2 and HLA-B7 antigens were compared using a sensitive radioimmunoassay method. There was no difference between age- and sex-matched patient groups.

摘要

采用血清学方法对来自芬兰北部的60例多发性硬化症患者测定了由A和B位点编码的24种HLA抗原。其中45例患者还通过混合淋巴细胞培养反应性对HLA-Dw2进行了分型。与对照组相比,这些患者抗原频率唯一具有统计学意义的差异是患者中HLA-A2的减少。采用灵敏的放射免疫测定法比较了有和没有HLA-Dw2及HLA-B7抗原的患者的麻疹和风疹抗体滴度。年龄和性别匹配的患者组之间没有差异。

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