交感神经元细胞体和神经末梢中酪氨酸羟化酶诱导的相位差异。
Phase difference in the induction of tyrosine hydroxylase in cell body and nerve terminals of sympathetic neurones.
作者信息
Thoenen H, Mueller R A, Axelrod J
出版信息
Proc Natl Acad Sci U S A. 1970 Jan;65(1):58-62. doi: 10.1073/pnas.65.1.58.
Abstract
The induction of tyrosine hydroxylase in the nerve terminals of the rat heart by reserpine lags behind that in the stellate ganglion by two to three days. Cycloheximide given three days after reserpine blocks the further rise of the enzyme in the nerve terminals. The increase in tyrosine hydroxylase activity of the lumbar ganglion is as marked as that in the stellate ganglion. The increase of enzyme activity in the sciatic nerve after reserpine administration resembles that found in the heart nerve terminals. Determination of enzyme activity in segments of sciatic nerves indicates a two-day lag and then a proximal-distal transport of enzyme, but the apparent rate is not sufficient to account for the increase in enzyme in the nerve terminals. These findings are compatible with the local synthesis of induced tyrosine hydroxylase in the nerve terminals rather than the peripheral movement of the completed enzyme.
摘要
利血平诱导大鼠心脏神经末梢中酪氨酸羟化酶的过程比星状神经节滞后两到三天。利血平给药三天后给予环己酰亚胺可阻断神经末梢中该酶的进一步升高。腰神经节中酪氨酸羟化酶活性的增加与星状神经节中的增加一样显著。利血平给药后坐骨神经中酶活性的增加与心脏神经末梢中的情况相似。对坐骨神经节段中酶活性的测定表明存在两天的滞后，然后是酶的近端到远端运输，但明显的速率不足以解释神经末梢中酶的增加。这些发现与神经末梢中诱导型酪氨酸羟化酶的局部合成相一致，而不是完整酶的外周移动。
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